Can nodular fasciitis be misdiagnosed?
Can nodular fasciitis be misdiagnosed?
Nodular fasciitis is a reactive proliferation of fibroblasts/myofibroblasts in the fascia and subcutaneous tissue. Histological examination sometimes reveals cellular heterotypia and polymorphism. Therefore, nodular fasciitis is often misdiagnosed as soft tissue sarcoma.
What is USP6 gene rearrangement?
USP6 rearrangement is a consistent genetic finding in aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesions of small bones. We report herein the occurrence of USP6 rearrangement in fibro-osseous pseudotumors of the digits using fluorescence in situ hybridization analysis (FISH).
What is nodular fibromatosis?
Nodular fasciitis is a fast-growing lump in your soft tissue. It’s not clear why you get it, but it’s not cancerous. It’s sometimes called pseudosarcomatous fasciitis, proliferative fasciitis, or infiltrative fasciitis. It’s a noncancerous skin growth in your soft tissue.
Does nodular fasciitis go away?
Nodular fasciitis is a harmless tumor with an excellent outlook. Sometimes it resolves without any treatment. The tumor resolves with surgery, including partial surgery. Some tumors may be treated with corticosteroids.
What is aneurysmal bone cyst?
An aneurysmal bone cyst is a benign, blood-filled lesion in the bone that tends to expand or grow. While it is referred to as a cyst, it is a true benign bone tumor surrounded by a thin wall of bone. Aneurysmal bone cysts (ABCs) can occur in any bone, but are most commonly found around the knee, pelvis or spine.
How is nodular fasciitis diagnosed?
Imaging by sonogram, MRI scan, or CT scan can help characterize features of nodular fasciitis. FNAC followed by an analysis of tissue histology can help make a definitive diagnosis. Sometimes the diagnosis isn’t confirmed until the tumor is surgically removed.
Where does nodular fasciitis occur?
Nodular fasciitis (NF) is a benign, soft tissue tumor composed of myofibroblasts (i.e. immature cells that contain features of myocytes and fibroblasts) that typically occurs in subcutaneous tissue (i.e. lowermost layer of the skin), fascia (i.e. band of connective tissue just beneath the skin), and/or muscles.
How common are aneurysmal bone cysts?
An aneurysmal bone cyst (ABC) is a highly destructive benign bone tumor, occurring in less than 1 in 100,000 people per year. The term “aneurysmal” refers to the explosive, expansile nature of the bone containing the aneurysmal bone cyst, similar to the enlargement seen with blood vessel or heart aneurysms.
What is USP6 rearrangement in nodular fasciitis?
Recently, rearrangement of the ubiquitin-specific protease 6 (USP6) gene has been reported as a recurrent and specific finding in nodular fasciitis.
What is the USP6 FISH test?
USP6 FISH is a useful ancillary test in cases where nodular fasciitis is a potential diagnostic consideration. USP6 FISH is a useful ancillary test in cases where nodular fasciitis is a potential diagnostic consideration. USP6 gene rearrangement in nodular fasciitis and histological mimics
What is the pathophysiology of nodnodular fasciitis?
Nodular fasciitis is a self-limited myofibroblastic lesion that can be misdiagnosed as a sarcoma as a result of its rapid growth, cellularity, and sometimes prominent mitotic activity.
Which antigen is positive in nodular fasciitis?
The cells are positive for smooth muscle actin; they are negative for desmin, S100, CD34 and epithelial membrane antigen. Most cases of nodular fasciitis are characterized by which of the following gene fusions?
