Can Precedex cause rebound tachycardia?

Can Precedex cause rebound tachycardia?

A discontinuation syndrome manifest as rebound agitation, hypertension, and tachycardia is recognized after prolonged clonidine infusion and has occasionally been reported with dexmedetomidine. When stopping the drug, patients should be monitored for symptoms and if apparent should prompt a more gradual dose reduction.

Does dexmedetomidine cause tachycardia?

In Summary. Common side effects of Precedex include: bradycardia, hypotension, agitation, hypertension, nausea, and tachycardia. Other side effects include: vomiting, and xerostomia.

How does dexmedetomidine produce transient hypertension?

Rapid intravenous administration of dexmedetomidine can cause transient hypertension due to weak peripheral α1 receptor agonist activity. This effect may be avoided by administering the loading dose slowly. During the infusion, modest hypotension and bradycardia may occur, particularly at higher doses.

Does precedex affect heart rate?

Patients who receive dexmedetomidine and develop a greater than 30% decrease in heart rate may be at high risk for severe bradycardia leading to pulseless electrical activity. We urge caution when using dexmedetomidine, especially in patients with significant cardiac disease.

Is precedex better than propofol?

Conclusions: For ICU patient sedation, dexmedetomidine may offer advantages over propofol in terms of decrease in the length of ICU stay and the risk of delirium. However, transient hypertension may occur when dexmedetomidine is administered with a loading dose or at high infusion rates.

Why is precedex bad?

Because Precedex decreases sympathetic nervous system activity, hypotension and/or bradycardia may be expected to be more pronounced in patients with hypovolemia, diabetes mellitus, or chronic hypertension and in elderly patients.

What is precedex used for in ICU?

Precedex™ is indicated for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Precedex should be administered by continuous infusion not to exceed 24 hours.

Why can precedex only be used for 24 hours?

The FDA states that if used for >24 hours, dexmedetomidine can cause tolerance and tachyphylaxis. The FDA also states that prolonged exposure can cause a dose-related increase in adverse events such as acute respiratory distress syndrome (ARDS), respiratory failure and agitation.

Why is Precedex bad?

What are the Common side effects of Precedex?

Common side effects of Precedex include: 1 low or high blood pressure (hypotension or hypertension), 2 slow heart rate (bradycardia), 3 nausea, 4 dry mouth, 5 irregular heartbeat, 6 (more items)

What is the incidence of tachycardia and hypertension after discontinuation of Precedex?

In adult subjects, tachycardia and hypertension requiring intervention in the 48 hours following study drug discontinuation occurred at frequencies of <5%. If tachycardia and/or hypertension occurs after discontinuation of Precedex supportive therapy is indicated.

How is bradycardia induced by Precedex treated?

Because Precedex has the potential to augment bradycardia induced by vagal stimuli, clinicians should be prepared to intervene. The intravenous administration of anticholinergic agents (e.g., glycopyrrolate, atropine) should be considered to modify vagal tone.

What are the treatment options for Precedex (Precedex infusion)?

If medical intervention is required, treatment may include decreasing or stopping the infusion of Precedex, increasing the rate of intravenous fluid administration, elevation of the lower extremities, and use of pressor agents.