Can vitamin K be given SQ?

Can vitamin K be given SQ?

However, for most patients, subcutaneous vitamin K1 is an effective and safe alternative when used in conjunction with modification of subsequent warfarin dosing, because virtually all patients achieved a safe level of anticoagulation within 72 hours with this route of administration.

When is IV vitamin K appropriate?

Intravenous infusion is preferred in situations when more rapid reversal of anticoagulation is required. A significant effect on the INR is usually evident within 4-6 hours after IV administration of vitamin K. The required dose (usually 5-10 mg) is added to 50 mL of D5W and infused over 15-30 minutes.

Where should vitamin K be injected?

This medication is given by injection under the skin or into a muscle or vein as directed by your doctor. If this medication is given into a vein, it should be injected very slowly (no more than 1 milligram per minute) to reduce the risk of serious side effects.

At what INR should vitamin K be given?

A 1.0-mg vitamin K dose is likely most appropriate for patients with INR values between 4.5 and 10. The fear of over-correction of the INR has limited the widespread use of vitamin K; however, our review suggests that this occurs infrequently when small doses are administered orally.

How quickly does vitamin K affect INR?

A dose of 1-2.5mg of oral phytomenadione (vitamin K(1)), reduces the range of INR from 5.0-9.0 to 2.0-5.0 within 24-48 hours, and for an INR >10.0, a dose of 5mg may be more appropriate. Overcorrection of the INR or resistance to warfarin is unlikely if the above doses of vitamin K are used.

How do you administer vitamin K IV?

1. If phytonadione is to administered intravenously, dilute in 50 ml of normal saline or dextrose solution and administer over 60 minutes. Monitor vital signs every 15 minutes x 4, then every 30 minutes x 2. IV phytonadione is never given IV push.

Does vitamin K raise or lower your INR?

Vitamin K can change how warfarin works, which changes your INR. Vitamin K lowers your INR values. The lower your INR, the less time it takes for your blood to clot.

Does Vitamin K2 thicken or thin the blood?

One study showed that a single serving of natto rich in vitamin K2 altered measures of blood clotting for up to four days. This was a much larger effect than foods high in vitamin K1 ( 10 ).

Should I use vitamin K?

The decision whether or not to use vitamin K should be based on several factors which will not be addressed now. Vitamin K can be administered by the oral, intravenous, intramuscular, or subcutaneous routes.

Is it safe to administer Vitamin K through the subcutaneous route?

However, there is a small risk of an anaphylactic reaction with the intravenous preparation. Vitamin K is absorbed rapidly by the subcutaneous route. Therefore, the subcutaneous route is preferable unless problems are anticipated with subcutaneous absorption, such as might occur in patients with severe peripheral circulatory failure.

What is the difference between oral and injectable vitamin K?

Background:Vitamin K, or phytonadione, is available in both injectable and oral formulations. Oral vitamin K is available as 5-mg tablets, but the key drawbacks for using vitamin K tablets consist of availability of only 1 dose strength and recent tripling of the product’s cost over a 2-year period.

How is vitamin K administered in Canada?

At the time of the study, the tablet formulation of vitamin K was not available in Canada, and thus, the protocol required oral administration of injectable vitamin K. An insulin syringe with a filter needle was used to draw up 1 mg of vitamin K, which was then administered orally.