Does calcitonin cause bone pain?
Does calcitonin cause bone pain?
Bone pain is the most common symptom in osteoporotic patients. To date, there is mounting evidence that calcitonin significantly reduces bone pain in osteoporosis, and that the analgesic effect can be evident as soon as the second week of treatment.
What is the mechanism of action of calcitonin in the treatment of osteoporosis?
Calcitonin reduces calcium levels in the blood by two main mechanisms: It inhibits the activity of osteoclasts, which are the cells responsible for breaking down bone. When bone is broken down, the calcium contained in the bone is released into the bloodstream.
Why is calcitonin used to treat osteoporosis?
Calcitonin is a hormone naturally produced in the thyroid. When given to patients with osteoporosis, calcitonin produces modest increases in bone mass because it slows the rate at which osteoclasts absorb bone. Only women who are at least five years past menopause can take calcitonin.
How does calcitonin work for pain?
The analgesic action of calcitonin may be mediated by restoration of serotonin receptors that control selective glutamate release from C-afferent fibers in ovariectomized rats and by normalization of sodium channel expression in damaged peripheral nerves.
Does calcitonin help bone pain?
Calcitonin has been demonstrated to be clinically useful in improving pain, not only from the acute vertebral fractures of osteoporosis, but also in Paget’s disease, bone malignancies, and other sources of musculoskeletal pain.
Why is calcitonin a nasal spray?
Calcitonin nasal spray is used together with calcium and vitamin D to treat bone loss in women with postmenopausal osteoporosis who have been postmenopause for at least 5 years. This product is available in the following dosage forms: Spray.
How does calcitonin affect calcium?
Calcitonin works to control calcium and potassium levels. It does this by inhibiting the activity of the osteoclasts, the cells that break down bone. When the osteoclasts break down bone tissue, the calcium enters the bloodstream.
How does calcitonin work for hypercalcemia?
CALCITONIN Pharmacologic doses of calcitonin reduce the serum calcium concentration by increasing renal calcium excretion and, more importantly, by decreasing bone resorption via interference with osteoclast function [10,11].
Why is estrogen important for bones?
Estrogen plays an important role in the growth and maturation of bone as well as in the regulation of bone turnover in adult bone. During bone growth estrogen is needed for proper closure of epiphyseal growth plates both in females and in males.
What are the main functions of calcitonin?
Calcitonin is a hormone that the C-cells in the thyroid gland produce and release. It opposes the action of the parathyroid hormone, helping to regulate the blood’s calcium and phosphate levels. How does calcitonin work? Calcitonin works to control calcium and potassium levels.
What is calcitonin given for?
Calcitonin injection is used to treat Paget’s disease of the bone. It may also be used to prevent bone loss in women with postmenopausal osteoporosis and to treat hypercalcemia (too much calcium in the blood).
Which is a therapeutic effect of calcitonin?
Calcitonin is a potent hormonal inhibitor of bone resorption. Its major therapeutic effect is in the treatment of Paget’s Disease of bone, in which it has been shown to reduce bone pain, lead to radiological and histological improvement in bone, and to restore abnormal biochemistry towards normal.
Does calcitonin reduce bone pain in osteoporosis?
To date, there is mounting evidence that calcitonin significantly reduces bone pain in osteoporosis, and that the analgesic effect can be evident as soon as the second week of treatment. The limitations to the use of calcitonin, which ar … Bone pain is the most common symptom in osteoporotic patients.
Can calcitonin be used to treat vertebral collapse?
Vertebral collapse is a common fracture associated with osteoporosis. Subsequent pain may be severe and often requires medications and bed rest. Several studies have suggested the use of calcitonin for the treatment of fracture pain.
What is the mechanism of action of calcitonin?
The analgesic action of calcitonin may be mediated by restoration of serotonin receptors that control selective glutamate release from C-afferent fibers in ovariectomized rats and by normalization of sodium channel expression in damaged peripheral nerves.
Does calcitonin have an analgesic role in fracture prevention?
Background and objectives: Calcitonin is a polypeptide hormone regulating the metabolism calcium in the body. For many years calcitonin has been used to maintain and improve bone mineral density and to reduce the fracture rate. Many studies showed that calcitonin had analgesic role in several painful circumstances.
