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Does niacin inhibit hormone sensitive lipase?

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Does niacin inhibit hormone sensitive lipase?

Niacin is thought to inhibit hormone-sensitive lipase (HSL) and enhance lipoprotein lipase (LPL) expression in peripheral fat. Conversely, it inhibits LPL and enhances HSL expression in intra-abdominal fat (IAF) (Farmer and Gotto 1996).

Does niacin inhibit HSL?

Niacin acts on its receptor GPR109A on adipocytes, lowering cAMP and protein kinase A levels. PKA phosphorylates hormone sensitive lipase (HSL). Therefore, niacin decreases HSL and TG hydrolysis in adipocytes, which causes a suppressed level of plasma FFAs.

What hormone stimulates lipolysis?

Glucagon, adrenocorticotropic hormone, α-melanocyte-stimulating hormone, and thyroid-stimulating hormone also induce lipolysis through G s proteins. Adenosine suppresses lipolysis by binding to receptors that activate inhibitory G proteins (G i).

What are the side effects of taking niacin?

High doses of niacin available via prescription can cause:

  • Severe skin flushing combined with dizziness.
  • Rapid heartbeat.
  • Itching.
  • Nausea and vomiting.
  • Abdominal pain.
  • Diarrhea.
  • Gout.
  • Liver damage.

What are the indications for niacin?

Indications

  • Reduce elevated TC, LDL-C, Apo B and TG levels, and to increase HDL-C in patients with primary hyperlipidemia and mixed dyslipidemia.
  • Indicated to reduce the risk of recurrent nonfatal myocardial infarction in patients with history of MI and hyperlipidemia.

Can niacin cause hepatitis?

Hepatitis developed in five patients who were taking low dosages (3 g/day or less) of time-release niacin. In four of the five patients, clinical symptoms of hepatitis developed after the medication had been taken for a relatively short time (2 days to 7 weeks).

Can niacin cause high liver enzymes?

Niacin can cause mild-to-moderate serum aminotransferase elevations and high doses and certain formulations of niacin have been linked to clinically apparent, acute liver injury which can be severe as well as fatal.

Can niacin cause low platelets?

FDA prescribing literature states that extended-release (ER) niacin (Niaspan, Abbott Laboratories) is associated with a “statistically significant dose-dependent reduction in platelet counts, with an average drop of −11% on a dose of 2,000 mg/day” 1.

What triggers hormone sensitive lipase?

Stimulation of β-ARs in adipose tissue activates hormone sensitive lipase, initiating lipolysis, the breaking down of triacyglycerols into free fatty acids and glycerol. Once mobilized, these free fatty acids bind to albumin in the blood, and are delivered to organs/tissues.

What does hormone sensitive lipase do?

Function. The main function of hormone-sensitive lipase is to mobilize the stored fats . HSL functions to hydrolyze either a fatty acid from a triacylglycerol molecule, freeing a fatty acid and diglyceride, or a fatty acid from a diacylglycerol molecule, freeing a fatty acid and monoglyceride.

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