Does nifedipine cause gum swelling?

Does nifedipine cause gum swelling?

Nifedipine is one of the commonest antihypertensive drugs (calcium channel blockers) used to treat hypertension and some forms of angina. Though it has various side effects, gingival enlargement is the most attended side effect which is of great importance in dentistry.

Does amlodipine affect gums?

Gingival enlargement is one of the side effects associated with certain drugs. Amlodipine, a calcium channel blocker, used as antihypertensive drug has been found associated with gingival hyperplasia.

What causes gingival hypertrophy?

Gingival hyperplasia can occur as a direct result of inflammation. The inflammation is often caused by plaque buildup on the teeth from food, bacteria, and poor hygiene practices. The inflammation can make the gums tender and red, and it can trigger bleeding.

Which antiepileptic causes gum hypertrophy?

Phenytoin is the drug, which can be chiefly implicated for causing gingival overgrowth. Sodium valproate carries the potential for gingival overgrowth, although only up to clinically insignificant levels in 6 months. Carbamazepine can be considered a safe drug in children in relation to gingival overgrowth.

Does nifedipine cause gingival hyperplasia?

Drug-induced gingival overgrowth is frequently associated with three particular drugs: phenytoin, cyclosporin, and nifedipine. As gingival enlargement develops, it affects the normal oral hygiene practice and may interfere with masticatory functions.

Does verapamil cause gingival hyperplasia?

Gingival overgrowth is the most common dental AE of antiepileptics. Phenytoin, phenobarbital, valproate, cyclosporine, tacrolimus, nifedipine, verapamil, and amlodipine are known to cause gingival overgrowth3,5,6,8-11; these drugs affect fibroblast function, increasing the matrix of the gingival connective tissue.

Can amlodipine cause gum hypertrophy?

Amlodipine is a second-generation dihydropyridine calcium channel blocker that can cause gingival hypertrophy. The prevalence of amlodipine-induced gingival hypertrophy has been shown to be between 1.7% and 3.3%.

Can amlodipine cause sore gums?

In some patients, tenderness, swelling, or bleeding of the gums may appear soon after treatment with this medicine is started. Brushing and flossing your teeth carefully and regularly and massaging your gums may help prevent this.

Is gingival hyperplasia bad?

Gingival hyperplasia is often a painful condition that can cause red and/or bleeding gums. Other symptoms of gingival enlargement include bad breath, plaque buildup on teeth, and tender/inflamed gums. This condition also negatively impacts your oral health standing.

What are the drugs causing gingival hyperplasia?

Drug-induced gingival overgrowth is a side effect associated principally with 3 types of drugs: anticonvulsant (phenytoin), immunosuppressant (cyclosporine A), and various calcium channel blockers (nifedipine, verapamil, diltiazem).

Why phenytoin causes gum hypertrophy?

Phenytoin has been shown to induce gingival overgrowth by its interaction with a subpopulation of sensitive fibroblasts. Cyclosporine has been suggested to affect the metabolic function of fibroblast (eg, collagen synthesis, breakdown).

Does diltiazem cause gingival hyperplasia?

A small study of 89 patients undertaken at the Westside Veterans Administration Medical Center, Chicago seems to indicate that nifedipine and diltiazem do indeed cause gingival hyperplasia.

What are the causes of gingival hyperplasia?

3 Causes of gingival hyperplasia 1 Inflammatory gum enlargement. 2 Systemic causes. 3 Hereditary gingival fibromatosis.

What causes hypertrophy of the gums?

Systemic causes of gum hypertrophy. There are numerous physiologic and systemic conditions that may promote localized and/or generalized gingival enlargement such as pregnancy, hormonal imbalances, and leukemia.

Can calcium channel blockers cause gingival hypertrophy?

Anticonvulsants, antihypertensive calcium channel blockers and immunosuppressants are the three main classes of drugs known to cause drug-induced gingival hypertrophy or hyperplasia. Among the calcium channel blockers, nifedipine administration has most frequently been associated with medication-related gingival hyperplasia.

What is hereditary gingival fibromatosis (HGF)?

Hereditary gingival fibromatosis (HGF) is a rare oral condition that causes slow, progressive gum enlargement. It often begins in childhood, but it may not be noticeable until adulthood. The gingival overgrowth from this condition is caused by an overproduction of collagen.