Does platelet transfusion require blood group matching?
Does platelet transfusion require blood group matching?
When considering a platelet transfusion, one must consider the ABO compatibility of the platelets themselves, as well as the accompanying plasma. Platelets, like red blood cells (RBCs), express ABO antigens, although expression is variable and strongly expressed in only 4% to 7% of individuals.
What are the indications for platelet transfusion?
Indications for Transfusion of Platelets in Adults
| Prophylactic transfusion indications | Platelet count (× 103 per μL) |
|---|---|
| Major surgery or invasive procedure, no active bleeding | ≤ 50 |
| Ocular surgery or neurosurgery, no active bleeding | ≤ 100 |
| Surgery with active bleeding | < 50 (usually) |
| > 100 (rarely) |
When do you use HLA matched platelets?
HLA-matched platelets are indicated for patients that have thrombocytopenia and have demonstrated CCI values consistent with immune refractory thrombocytopenia on at least two occasions.
Does blood type matter for platelet transfusion?
ABO and Platelets It is well known that the appropriate matching of compatible ABO blood groups is critical for safe red blood cell transfusion. The source of this requirement is the interaction of antigens on the surface of the red blood cell and antibodies in the plasma.
Do platelets require crossmatch?
Crossmatching of plasma is not required, since there are no RBCs in these products. Platelets: Platelets are transfused in patients with thrombocytopenia if they are bleeding, if prophylaxis against spontaneous bleeding is required or if a platelet count threshold needs to be surpassed before an invasive procedure.
Do you crossmatch platelets?
Cross-match-compatible platelets are used to support thrombocytopenic patients who are refractory to randomly selected platelets. However, few studies have addressed the efficacy of using this strategy for patients requiring intensive platelet transfusion therapy.
What are apheresis platelets?
Apheresis platelets are collected from a single donor by using an apheresis machine with an integrated leucoreduction system (removing ≥ 99% white cells). The machine draws blood from the donor, isolates the platelets and some plasma by centrifugation and returns the remaining blood back to the donor.
When is platelet transfusion contraindicated?
Platelet transfusions are contraindicated in patients with thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), or heparin induced thrombocytopenia (HIT).
What are matched platelets?
What is an HLA-matched platelet? Human Leukocyte antigens (HLA) are proteins that are found on most cells in your body including platelets. An HLA-matched platelet is a blood component from a blood donor with an HLA type very similar to your own.
What is HLA matching?
A process in which blood or tissue samples are tested for human leukocyte antigens (HLAs). HLA matching is done before a donor stem cell or organ transplant to find out if tissues match between the donor and the person receiving the transplant. Also called human leukocyte antigen matching.
Which blood group can donate platelets?
All blood types, except for type O negative and type B negative, are encouraged to try platelet donation. Type O negative and type B negative can make the most impact for patients in need by continuing to give whole blood or a Power Red donation.
Can O+ donate platelets to AB?
The red blood cells from O- blood donors can be transfused into any patient needing blood. Just as AB+ is the universal blood type for platelets, O neg is the universal blood type for red cells. Just 7% of the population has O- blood, so that’s why O- donors should always give red blood cells.
What are the clinical indications for platelet transfusion?
Clinical Indications for platelet transfusion for patients with clinically signifi- cant bleeding include: 1. Platelet transfusion is indicated for patients with clinically significant bleeding in whom thrombocytopenia is thought to be a major contributory factor, even if the platelet count is >10×109/L. 2.
What is plaqueplatelet transfusion?
Platelet transfusion is indicated for the treatment and prevention of bleeding in patients with. severe thrombocytopaenia and/or impaired platelet production and/or function.1.
What are the contraindications for platelet transfusion?
Platelet transfusion may be indicated to prevent hemorrhage in patients with thrombocytopenia or platelet function defects. Contraindications to platelet transfusion include thrombotic thrombocytopenic purpura and heparin-induced thrombocytopenia.
What is the evidence for the use of plasma transfusion?
There is moderate evidence for the use of plasma and platelet transfusion in patients receiving massive blood transfusion. There is not enough evidence to support the use of plasma, platelets and cryoprecipitate in any other clinical setting.
