How do ocular inserts work?
How do ocular inserts work?
They offer several advantages as increased ocular residence and sustained release of medication into the eye. The insert includes a body portion sized to position within a lachrymal canaliculus of the eyelid. The inserts are classified according to their solubility as insoluble, soluble, or bioerodible inserts.
What are the drug release mechanism in implants?
Mechanisms of drug release from implantable systems are mainly classified into four groups: matrix degradation; controlled swelling; osmotic pumping; and passive diffusion [19]. For systems based on controlled swelling, solvent penetration into the matrix of the device controls the rate of release.
What is Occuserts?
➢Ocular insert (Ocusert) are sterile preparation that. prolong residence time of drug with a controlled release manner and negligible or less affected by nasolacrimal drainage. ➢It shows diffusion controlled release. ➢It consists of a central reservoir of drug enclosed in. specially designed microporous membrane …
What is novel drug delivery system?
Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems. If the novel drug delivery technology is applied in herbal medicine, it may help in increasing the efficacy and reducing the side effects of various herbal compounds and herbs.
What physiological factors affect Mucoadhesion?
Several polymer related factors like molecular weight, chain length, degree of cross-linking, hydration, functional groups, charge, polymer concentration and several environmental and physiological factors like contact time, mucin turnover rate and mucus viscosity affect the degree of mucoadhesion.
What is limitation of Tdds?
Common disadvantages of TDDS: 1,3-5 Many drugs especially drugs with hydrophilic structures permeate the skin too slowly may not achieve therapeutic level. 2. The drug, the adhesive or other excipients in the patch formulation can cause erythema, itching, and local edema.
What is Norplant birth control?
Norplant consists of six matchstick-size silicone capsules that are inserted in a woman’s upper arm. The capsules release small amounts of progestin over five years and must be inserted and removed by a trained medical professional. Norplant is an extremely effective contraceptive.
Which of the following drugs are used in implants?
Which of the following drugs are used in implants? Explanation: Drugs which are generally used for such implants are steroids like contraceptives, morphine antagonists like naltrexone for opioid-dependent addicts. Polymers used for making such implants are polymethacrylates, elastomers, etc.
Which are types of novel drug delivery system?
NOVEL DRUG DELIVERY SYSTEMS: AN OVERVIEW
| Trade Name | Trade Name | Manufacturer |
|---|---|---|
| Abelcet | Amphotericin B | The Liposome Company |
| Amphotec | Amphotericin B | Sequus Pharmaceuticals |
| Doxil | Doxorubicin | Sequus Pharmaceuticals |
| DaunoXome | Daunorubicin | NeXstar Pharmaceuticals |
What is a novel drug Why is it important?
Novel drugs are often innovative products that serve previously unmet medical needs or otherwise significantly help to advance patient care and public health. NMEs have chemical structures that have never been approved before.
What are Theory of mucoadhesion explain?
Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood.
What is bioadhesion and mucoadhesion?
For drug delivery purposes, the term bioadhesion implies attachment of a drug carrier system to a specified biological location. The biological surface can be epithelial tissue or the mucus coat on the surface of a tissue. If adhesive attachment is to a mucus coat, the phenomenon is referred to as mucoadhesion.
Where does bioerosion occur?
Bioerosion occurs in all biomes of the world from the ocean floor to arid deserts, and involves a wide diversity of taxa and mechanisms with varying ecological effects. Many abiotic and biotic factors affect bioerosion by acting on the bioeroder, substratum, or both.
What is Marine bioerosion?
Bioerosion describes the breakdown of hard ocean substrates – and less often terrestrial substrates – by living organisms. Marine bioerosion can be caused by mollusks, polychaete worms, phoronids, sponges, crustaceans, echinoids, and fish; it can occur on coastlines, on coral reefs, and on ships;
What is biobioerosion of coral reefs?
Bioerosion of coral reefs generates the fine and white coral sand characteristic of tropical islands.
What is IUPAC definition of bioerosion?
IUPAC definition. This definition describes the chemical process of bioerosion, specifically as it applies to biorelated polymers and applications, rather than the geological concept, as covered in the article text.
