How does automated CBC work?

How does automated CBC work?

The CBC is performed using basic laboratory equipment or an automated hematology analyzer, which counts cells and collects information on their size and structure. The concentration of hemoglobin is measured, and the red blood cell indices are calculated from measurements of red blood cells and hemoglobin.

What causes spurious mean cell volume?

Mean (red) cell volume (MCV) may be also subject to spurious determination, because of agglutinins, excess of glucose or salts and technological considerations.

What are the red blood cell indices and what tests are diagnostic for Ida?

Initial testing for IDA typically includes an assessment of hemoglobin (Hb), hematocrit (Hct), and red blood cell (RBC) indices such as mean corpuscular volume (MCV), followed by serum ferritin (SF) if Hb levels are 2 standard deviations below normal for age and sex.

What causes spurious decrease in MCV?

Decreased MCV (microcytosis) Hyponatremia: A falsely low MCV is an artifact of ADVIA (and potentially other) analyzers, that is caused by a hypoosmolar environment in vivo, e.g. hyponatremia, to which erythrocytes adjust by increasing cytoplasmic water content.

How quickly does MCV change?

MCV takes 6 to 8 weeks of heavy drinking—we which we define as consuming ≥40 grams of alcohol/ day5—to become elevated and returns to normal within 3 months of abstinence.

What can cause a falsely elevated hemoglobin?

What can cause a high hemoglobin count?

• Polycythemia vera (the bone marrow produces too many red blood cells)
• Lung diseases such as COPD, emphysema or pulmonary fibrosis (lung tissue becomes scarred)
• Heart disease, especially congenital heart disease (the baby is born with it)
• Kidney tumors.

What does RBC morphology abnormal mean?

RBCs carry oxygen and nutrients to your body’s tissues and organs. If your RBCs are irregularly shaped, they may not be able to carry enough oxygen. Poikilocytosis is usually caused by another medical condition, such as anemia, liver disease, alcoholism, or an inherited blood disorder.

Which of the following are characteristic of polycythemia vera?

Polycythemia vera is a condition characterized by an increased number of red blood cells in the bloodstream. Affected individuals may also have excess white blood cells and blood clotting cells called platelets. These extra cells and platelets cause the blood to be thicker than normal.

What does CBC with auto diff stand for?

“CBC with auto diff” is an abbreviation for a laboratory test called a complete blood count with automated differential. The test consists of group of measurements and counts performed by laboratory instrument 2.

What causes a high platelet count in CBC with auto diff?

Overproduction of platelets by the bone marrow and certain types of anemia are the leading causes of a high platelet count. “CBC with auto diff” is an abbreviation for a laboratory test called a complete blood count with automated differential. The test consists of group of measurements and counts performed by laboratory instrument.

What is CBC with differential blood useful for?

CBC with Differential, Blood Useful For Suggests clinical disorders or settings where the test may be helpful Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests. Testing Algorithm Delineates situations when tests are added to the initial order.

What do the different parts of a CBC Test mean?

Ask your healthcare provider what your test results mean for you. Normal ranges for the different parts of a CBC are: Red blood cells (RBC): 3.93 to 5.69 million per cubic millimeter (million/mm3) Red blood cell distribution width (RDW, RDW-CV, RDW-SD): 11.5% to 14.5%