How does epidermal growth factor work?
How does epidermal growth factor work?
Epidermal growth factor (EGF) is a common mitogenic factor that stimulates the proliferation of different types of cells, especially fibroblasts and epithelial cells. EGF activates the EGF receptor (EGFR/ErbB), which initiates, in turn, intracellular signaling.
How does EGF stimulate cell growth?
In general, binding of its ligand, epidermal growth factor (EGF), results in stimulation of the EGFR tyrosine kinase, which in turn stimulates intracellular signal transduction, enhances transcription of growth related genes, and promotes cell growth. …
How does EGF signal cells?
EGFR plays a crucial role in initiating the signaling that directs the behavior of epithelial cells and tumors of epithelial origin. Human EGF is a 53-aa polypeptide, whose molecular weight is 6KDa. EGF can stimulate the cell growth and differentiation by binding to its receptor, EGFR.
How does EGF create biological response?
EGF Receptors have an ability to escape lysosomal degradation and translocate into the nucleus to mediate biological functions. In the nucleus, these receptors promote transcription of cell survival genes like Cyclin D1 gene and also act as cofactors for STAT and E2F1 transcription factors18.
How does EGF result in tissue repair?
Epidermal growth factor (EGF) participates in dermal wound healing through stimulation, proliferation, and migration of keratinocyte, endothelial cells, and fibroblast and facilitates dermal regeneration.
What are the main target proteins of the EGF signaling pathway?
Three adaptor proteins, Shc, Grb2, and Gab1, bind to the activated EGFR via its autophosphorylated tyrosine residues. Shc binds to activated EGFR and is phosphorylated on its tyrosine 317. Grb2 binds to activated EGFR either directly or via Shc bound to activated EGFR.
Why is EGF important?
EGF is essential for mediating the de-differentiation of keratinocytes to an epithelial linage and to reestablish the epithelial barrier. EGF binds to the EGFR, a protein tyrosine kinase receptor, expressed on the majority of cells in the skin.
What is the mechanism of action of the EGF receptor?
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment Signaling by the epidermal growth factor receptor requires an allosteric interaction between the kinase domains of two receptors, whereby one activates the other.
What is the difference between EGF and EF-G?
Not to be confused with EF-G. Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-k Da and has 53 amino acid residues and three intramolecular disulfide bonds.
What is the role of EGF in human development?
The EGF family of growth factors appears to be important in mammalian development and function, although the precise roles and significance are not yet clear. Members of the EGF family may have a role in embryogenesis and fetal growth because receptors have been identified in fetal tissues.
What is epidermal growth factor (EGF) and how does it work?
Epidermal growth factor (EGF) is detectable by immunohistochemistry in most adenohypophysial cells and its mRNA is expressed with marked variation in all types of functional and nonfunctional adenomas. EGF potently stimulates PRL and adrenocorticotropic hormone secretion with variable effects on rat pituitary cell proliferation.
