How is cystatin C tested?
How is cystatin C tested?
Your body makes cystatin C constantly, and the protein is found in different fluids, including blood, spinal fluid, and breast milk. When your kidneys are healthy, they filter cystatin C out of the blood so it can be excreted in your urine. This is a fairly sensitive blood test to look at your kidney health.
What is cystatin C called in a blood test?
The level of creatinine in your blood and your age, race, and gender are used in a math formula to estimate your GFR. Another way to estimate GFR is with a simple blood test for cystatin C. Like creatinine, the cystatin C number is used in a math formula with your age, race, and gender to estimate your GFR.
What is the function of cystatin C?
Cystatin C is a low molecular-weight protein (13,000 Da) that is produced by all nucleated cells and acts to inhibit cysteine proteases. It has been used as an estimate of the severity of CKD because a high level of cystatin C is associated cardiovascular disease and may even be more closely associated than SCr.
How long does a cystatin C test take?
A Cystatin C Blood Test is used to screen for and monitor kidney dysfunction in those with known or suspected kidney disease. Preparation: Fasting for 10-12 hours required. Test Results: 3-5 days.
How much is a cystatin C test?
And while a cystatin C test may currently cost more than a serum creatinine assay, the price of the former is not prohibitive. At Karger’s institution, the University of Minnesota, a serum creatinine test costs about $2.50, while a cystatin C assay runs about $10.60.
How much does cystatin C cost?
Cystatin C test cost is between $55.75 and $310.42 Cystatin C test cost minimal is in DiscountedLabs (Cystatin C with EGFR Kidney Test) with price $55.75. Cystatin C test cost max is in Health Testing Centers (Cystatin C) with price $279.00. This laboratory test is available in 6 online lab test stores.
What is a normal level of cystatin C?
The range for cystatin C is 0.67-6.15 mg/l, 0.66-7.23 mg/dl for creatinine and 8.9-186.3 l/day (6.2-129.4 ml/min) for creatinine clearance. Serum cystatin C levels started to increase over normal range when creatinine clearance fell below 135.9 l/day (94.4 ml/min), while serum creatinine remained within normal ranges.
How do you control cystatin C?
Studies have shown that seniors with stronger muscles have better kidney function [83, 84]. Lose weight if overweight. It may help bring down your cystatin C levels [85]. Smoking is associated with higher cystatin C levels.
What is the importance of cystatin C as a marker for GFR?
Cystatin C is effectively filtered by the glomerulus and fully reabsorbed and broken down by the renal tubules for recycling. A raised level of serum or plasma cystatin C correlates closely with the GFR. Cystatin C therefore acts as an excellent indicator of reduced kidney function.
How much does a cystatin C test cost?
Cystatin C test cost is between $55.75 and $310.42 This laboratory test is available in 6 online lab test stores.
What is cystatin C and creatinine?
Cystatin C is made by all nucleated cells, not just muscle. As a result, cystatin C production varies less than creatinine production between individuals, and blood concentrations of cystatin C are fairly similar between individuals who have the same GFR. However, cystatin C has other potential confounders.
How do you calculate serum cystatin C?
The serum cystatin C was determined by an immunonephelometric method and our own cystatin C formula (GFR = 90.63 x cystatin C-1.192) for estimation of GFR was developed. GFR was measured using 51CrEDTA clearance, and the correlation, accuracy, bias and precision were determined.
What is cystatin C and why is it important?
What is cystatin C? Cystatin C is a protein that is produced by the cells in your body. When kidneys are working well, they keep the level of cystatin C in your blood just right. If the level of cystatin C in your blood is too high, it may mean that your kidneys are not working well. A blood test for cystatin C can help your healthcare provider
What is cystatin C and how is it used to measure GFR?
Like creatinine, the cystatin C number is used in a math formula with your age, race, and gender to estimate your GFR. The cystatin C test is not the usual or regular way that your healthcare provider will estimate your GFR. But it can be very helpful in some instances. When is cystatin C used to estimate GFR?
Is creatinine or cystatin C a more accurate test of kidney function?
Cross-sectional studies (based on a single point in time) suggest that serum levels of cystatin C are a more precise test of kidney function (as represented by the glomerular filtration rate, GFR) than serum creatinine levels..
What are the different types of inhibitors in the cystatin family?
There are three inhibitory families in the superfamily, including the type 1 cystatins ( stefins ), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions.
