How many genomes were sequenced as part of the 1000 Genomes?
How many genomes were sequenced as part of the 1000 Genomes?
The 1000 Genomes Project [10] which was launched in 2008, aims to provide the most detailed map of human genetic variation by sequencing about 2,500 genomes from about 25 global populations.
Why is there a 1000 genome Project?
The goal of the 1000 Genomes Project is to provide a resource of almost all variants, including SNPs and structural variants, and their haplotype contexts. This resource will allow genome-wide association studies to focus on almost all variants that exist in regions found to be associated with disease.
How do I download 1000 Genomes data?
The 1000 Genomes data is available via ftp, http, Aspera and Globus. Any standard tool like wget or ftp should be able to download from our ftp or http mounted sites. There are no official torrents of the 1000 Genomes Project data sets.
What is the purpose of the 1000 Genomes Project?
The 1000 Genomes Project is a collaboration among research groups in the US, UK, and China and Germany to produce an extensive catalog of human genetic variation that will support future medical research studies. It will extend the data from the International HapMap Project, which created a resource that has been used…
How difficult is it to identify HLA alleles from 1000 Genomes?
Given the limitation of both the coverage and the read length of the sequences generated by the 1000 Genomes Project, the highly variable positions that define HLA alleles may be difficult to identify.
What is the HLA typing assay?
The HLA typing assay was designed to capture the amino acid sequence of the Antigen Recognition Site (ARS) [22]. DNA samples were purchased from the Coriell Institute for Medical Research (Camden, NJ). The HLA typing data of 1,267 individuals related to the 1000 Genomes Project ( Table 1) covers 14 populations encompassing 4 major ancestral groups.
How many people in the world have HLA polymorphisms?
For example, in addition to HLA typing performed for solid organ transplantation, HLA polymorphisms have been determined in more than 23 million unrelated donors worldwide in order to match patients in need of hematopoietic stem cell transplantation, [4].
