How much does an organ-on-a-chip cost?
How much does an organ-on-a-chip cost?
We assessed the expected impact of organ-on-a-chip in comparison to the current costs of R&D per new drug. Cost estimates were derived from literature, because actual cost data are not publicly available. Cost estimates per new drug vary widely and range from US$330† [24], US$660† [2], US$2060 [8] to US$2760† [1].
What are human organs-on-chips?
4/7 The Organs-on-Chips are crystal clear, flexible polymers about the size of a computer memory stick that contain hollow channels fabricated using computer microchip manufacturing techniques. These channels are lined by living cells and tissues that mimic organ-level physiology.
Who started the organ-on-a-chip?
Donald Ingber
In 2010, Harvard’s Wyss Institute, led by Donald Ingber, produced the first successful chip, a lung model. Two years later Ingber’s lab was included in a public-private collaboration tasked with creating 10 different human organs-on-chips.
How do chips on organs work?
The organ-chips are designed to accurately recreate the natural physiology and mechanical forces that cells experience in the human body. The chips are lined with living human cells and their tiny fluidic channels reproduce blood and/or air flow just as in the human body.
What does organ-on-a-chip stand for?
A Wyss Institute-led collaboration spanning four research labs and hundreds of miles has used the institute’s organ-on-a-chip (Organ Chip) technology to identify the antimalarial drug amodiaquine as a potent inhibitor of infection with SARS-CoV-2, the virus that causes COVID-19.
What is the Wyss Institute doing with Organ-Chips?
The Wyss Institute is now using Emulate’s Organ-Chips to conduct vital research on a wide range of human diseases and possible treatments for them, including COVID-19, influenza, malnutrition, radiation exposure, and cystic fibrosis.
What can Organ Chips do for You?
With their ability to host and combine the different cell and tissue types making up human organs, Organ Chips present an ideal microenvironment to study molecular- and cellular-scale activities that underlie human organ function and mimic human-specific disease states, as well as identify new therapeutic targets in vitro.
Can microchips recapitulate the microarchitecture and functions of living organs?
Wyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier.
