Is 22q11 a form of autism?
Is 22q11 a form of autism?
An estimated 15 to 20 percent of those with DiGeorge meet the behavioral criteria for a diagnosis of autism spectrum disorder (ASD). In other words, some but not all individuals with DiGeorge have autism. DiGeorge is technically referred to as 22q11. 2 deletion syndrome (22q11DS).
What is chromosome 22q11 deletion syndrome?
DiGeorge syndrome, more accurately known by a broader term — 22q11. 2 deletion syndrome — is a disorder caused when a small part of chromosome 22 is missing. This deletion results in the poor development of several body systems.
How does 22q11 2 deletion syndrome happen?
22q11. 2 deletion syndrome is caused by a deletion of a small part of chromosome 22 near the middle of the chromosome at a location known as q11. 2. In most cases, the syndrome occurs for the first time in the affected person; about 10% of cases are inherited from a parent.
Is 22q11 2 deletion syndrome fatal?
Mortality in adults with 22q11. 2DS died at a median age of 41.5 (range 18.1–68.6) years. Table 2 shows age, cause of death, and accompanying features. Ten (83%) deaths were coroner’s cases; six of these had postmortem examinations.
What are the possible medical conditions associated with 22q11 deletion syndrome?
A large number of medical conditions may be associated with 22q11.2 deletion syndrome, such as hearing impairment, poor vision, breathing problems, poor kidney function and relatively short stature for one’s family. In some cases, DiGeorge syndrome (22q11.2 deletion syndrome) may be passed from an affected parent to a child.
Does early childhood autism predict psychotic disorders in children with 22q11DS?
Conclusion: Results indicate that in children with 22q11DS, early childhood autistic features are not associated with an increased risk for subsequent development of psychotic disorders or symptoms, replicating previous retrospective findings in adults with 22q11DS.
What are the possible complications of deletion syndrome?
Developmental delay, intellectual disability, and learning differences are also common in individuals with 22q11.2 deletion syndrome. Individuals may also have an autism spectrum disorders. Psychiatric illness, attention deficit disorder, anxiety, repetitive behaviors, and difficulty with social interactions are also common. [2]
Does deletion syndrome increase the risk of schizophrenia?
Background: Individuals with 22q11.2 deletion syndrome (22q11DS) have a 25% risk for schizophrenia and related psychotic disorders.
