Is amikacin effective against Pseudomonas aeruginosa?

Is amikacin effective against Pseudomonas aeruginosa?

Noteworthy is its effect against Pseudomonas aeruginosa and against most Gram-negative aerobes that are resistant to gentamicin and tobramycin. There are strains of Staphylococcus aureus that inactivate amikacin by phosphorylation and adenylation.

What is the best antibiotic for Pseudomonas aeruginosa?

At present, the use of newer penicillins, piperacillin, azlocillin, or selected antipseudomonal cephalosporins, in combination with amikacin or tobramycin, appears to be the preferable antimicrobial therapy for serious P. aeruginosa infections.

What is the drug of choice for Pseudomonas?

Ceftazidime is the antibiotic of choice because of its high penetration into the subarachnoid space and the high susceptibility of Pseudomonas to this drug. Initial therapy in critically ill patients should include an intravenous aminoglycoside.

Does amikacin have anaerobic coverage?

Amikacin is bactericidal with a broad spectrum of activity except against streptococci and anaerobic bacteria. Amikacin may have activity against many bacteria, especially gram-negative bacilli, that are resistant to other drugs.

Does Cipro treat Pseudomonas aeruginosa?

Ciprofloxacin was well tolerated. This new quinolone seems to be suitable for single drug treatment of Pseudomonas aeruginosa infections in patients with normal host defense mechanisms, while its therapeutic potential in compromised hosts requires further evaluation.

Are aminoglycosides active against Pseudomonas?

Aminoglycosides, and especially tobramycin, are clinically effective against P. aeruginosa when administrated intravenously or by nebulization in patients with CF.

Does Cipro cover Pseudomonas?

The antibiotic ciprofloxacin is used extensively to treat a wide range of infections caused by the opportunistic pathogen Pseudomonas aeruginosa. Due to its extensive use, the proportion of ciprofloxacin-resistant P. aeruginosa isolates is rapidly increasing.

Is ciprofloxacin effective against Pseudomonas?

A derivative of quinolinecarboxylic acid, ciprofloxacin (BAY o 9867) was found to be an effective bactericidal agent against Pseudomonas aeruginosa and Escherichia coli.

Does doxycycline cover Pseudomonas aeruginosa?

Pseudomonas aeruginosa ATCC 27853 and Escherichia coli ATCC 25922 were used as control strains. Testing against the P. aeruginosa strains revealed high MIC50 values for all the drugs except colistin. Doxycycline and colistin were both effective against the A.

Is doxycycline effective against Pseudomonas?

Polymyxin B–doxycycline in combination showed a synergistic effect against multi-drug-resistant Pseudomonas aeruginosa. Polymyxin B–doxycycline in combination enhanced bacterial killing and suppressed the emergence of resistant mutants.

Does ceftriaxone cover Pseudomonas?

Although ceftriaxone has some activity against Pseudomonas aeruginosa, on the basis of present evidence it cannot be recommended as sole antibiotic therapy in pseudomonal infections. Ceftriaxone has been effective in treating infections due to other ‘difficult’ organisms such as multidrug-resistant Enterobacteriaceae.

Do aminoglycosides cover Pseudomonas?

The aminoglycosides tobramycin, gentamicin, and amikacin are commonly used to treat hospital-acquired infections caused by Pseudomonas aeruginosa. These infections generally require treatment with a combination of antimicrobials in order to achieve a greater bactericidal effect and reduce the levels of resistance1.