Is CD34 a cancer?
Is CD34 a cancer?
In a recent study, investigators reported that CD34 expression is significantly lower in malignant tumors compared to their benign counterparts (2). CD34 is also used to distinguish between different subtypes of a particular cancer such as acute leukemia (3).
Are monocytes CD34-positive?
CD34-positive monocytes (CD34+mono) have recently been identified in grafts mobilized by granulocyte-colony stimulating factor. We analyzed transplant outcomes of 73 patients whose donor’s peripheral blood cells were cryopreserved during mobilization. CD34+mono was detected more frequently in male donors (67% vs.
What is CD117 positive?
Other mesenchymal tumors that were variably CD 117 positive included clear cell sarcoma (7 of 15), metastatic melanoma (9 of 25), and malignant fibrous histiocytoma (1 of 20). These results indicate that CD117 is a specific marker for GIST among tumors that occur in the GI tract and adjacent regions.
What CD34 means?
CD34 is predominantly regarded as a marker of hematopoietic stem cells (HSC) and hematopoietic progenitor cells. However, CD34 is now also established as a marker of several other nonhematopoietic cell types, including vascular endothelial progenitors 1 and embryonic fibroblasts 2.
What is a CD34 antibody?
A CD34 antibody is a human cellular molecule responsible for a number of different functions within the body. Located on the surface of the cell, the antibody acts as either a receptor or a ligand. As a receptor, the CD34 antibody is found within the plasma membrane or cytoplasm of a cell and signals other cells to perform certain actions.
What does antigens, CD34 mean?
Cluster of differentiation protocol that identifies cell surface antigens. CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species. CD34 derives its name from the cluster of differentiation protocol that identifies cell surface antigens.
What is benign spindle cell neoplasm?
A benign spindle cell neoplasm is a tumor that develops in connective tissue other than bone such as skeletal muscle, fat, tendon, fibrous tissue and nerve and blood vessel tissue. The most common benign soft tissue tumor is called a lipoma.
