Is cytarabine the same as cytosine arabinoside?

Is cytarabine the same as cytosine arabinoside?

Cytarabine, also known as cytosine arabinoside (ara-C), is a chemotherapy medication used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and non-Hodgkin’s lymphoma.

What is cytarabine made from?

Cytarabine (Cytosar) is a compound isolated from a sea sponge. It has also been referred to as cytosine arabinoside and Ara-C. Cytarabine is metabolized to an active drug that inhibits DNA synthesis.

How is cytarabine metabolized?

Cytarabine is metabolized intracellularly into its active triphosphate form (cytosine arabinoside triphosphate). This metabolite then damages DNA by multiple mechanisms, including the inhibition of alpha-DNA polymerase, inhibition of DNA repair through an effect on beta-DNA polymerase, and incorporation into DNA.

How is cytarabine cleared?

It has an active metabolite- azacytidine triphosphate; and an inactive metabolite- uracil arabinoside, which is cleared by the kidney.

Is cytosine arabinoside a chemotherapy drug?

Cytarabine is a type of chemotherapy drug and is also known by its brand name, Ara C. It is a treatment for: acute leukaemias (cancers of the blood)

How toxic is cytarabine?

The main toxic effect of cytarabine injection is bone marrow suppression with leukopenia, thrombocytopenia and anemia. Less serious toxicity includes nausea, vomiting, diarrhea and abdominal pain, oral ulceration, and hepatic dysfunction.

How long does cytarabine stay in your body?

Nadir: White blood cells: 7-10 days, platelets: 12-15 days.

Do you lose your hair with cytarabine?

This medicine may cause a temporary loss of hair in some people. After treatment with cytarabine has ended, normal hair growth should return.

What is cytosine arabinoside made of?

The cytosine arabinoside combines a cytosine base with an arabinose sugar. It is an antimetabolic agent with the chemical name of 1β-arabinofuranosilcitosina. Certain sponges, where it was originally found, use arabinoside sugars to form a different compound (which is not part of the DNA).

What is arabinoside used to treat?

Also known as cytosine arabinoside (ara-C), it is a chemotherapy drug used to treat acute myeloid leukemia (AML). As well as to treat acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML) and non-Hodgkin’s lymphoma .

Why is arabinoside used in sponges?

Certain sponges, where it was originally found, use arabinoside sugars to form a different compound (which is not part of the DNA). The cytosine arabinoside is sufficiently similar to human cytosine deoxyribose (deoxycytidine) to be incorporated into human DNA, but different enough to kill the cell.

What is another name for arabinofuranosyl cytidine?

It is also known as ara-C (arabinofuranosyl cytidine): Cytosar-U. Tarabine PFS (Pfizer). Depocyt (liposomal formulation of longer duration). Vehicle.