Is GLUT5 an active transporter?
Is GLUT5 an active transporter?
GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine….GLUT5.
| SLC2A5 | ||
|---|---|---|
| Entrez | 6518 | 56485 |
| Ensembl | ENSG00000142583 | ENSMUSG00000028976 |
| UniProt | P22732 | Q9WV38 |
What transports fructose?
Conclusions: Fructose is transported transcellularly by facilitated diffusion and paracellularly (based on lactulose transport) via glucose-activated solution drag. In the human small intestine, free fructose and glucose transport does not occur via the disaccharidase system.
How is fructose transported into the cell?
Fructose is transported across the cell membrane of enterocytes via passive transport, in which a membrane protein helps move the fructose without using any ATP molecules. However, both galactose and glucose are transported into the cell by using a sodium-linked secondary active transport system.
What is the function of GLUT7?
GLUT7 is a newly discovered, facilitated hexose transporter present in the BBM of the intestine and can transport glucose and fructose (Cheeseman, 2008).
Where is GLUT5 located?
GLUT5 (SLC2A5) is a high-affinity fructose transporter primarily expressed at the apical surface of intestinal epithelial cells but also at lower levels in testis, kidney, brain, skeletal muscle and white adipose tissue (WAT)15.
Is GLUT5 a protein?
GLUT5 appears to be the only GLUT protein with a high specificity for fructose and is the most divergent member of the glucose transporter family. Human GLUT5 shares 42%, 40%, 39%, and 42% identity with human GLUT1, GLUT2, GLUT3, and GLUT4, respectively.
Is GLUT5 a glucose transporter?
GLUT5 is a 501-amino-acid transmembrane protein that transports fructose and glucose molecules. Fructose is transported from the enterocyte into the portal circulation via the basolateral membrane GLUT2 transporter.
Is glucose an active transport?
There are two mechanisms for glucose transport across cell membranes. In the intestine and renal proximal tubule, glucose is transported against a concentration gradient by a secondary active transport mechanism in which glucose is cotransported with sodium ions.
How many glucose transporters are there?
There are five known Class III glucose facilitative transporters, namely, GLUT6, GLUT8, GLUT10, GLUT12 and GLUT13 (HMIT).
Where are GLUT1 transporters found?
mammalian erythrocyte membrane
GLUT1 is highly abundant in the mammalian erythrocyte membrane where it can rapidly equilibrate glucose between the cytoplasm of the erythrocyte and the blood plasma. GLUT1 is also found in brain tissues. GLUT1 can also transport mannose, galactose, and glucosamine.
