Is Minimal change disease the same as nephrotic syndrome?

Is Minimal change disease the same as nephrotic syndrome?

Minimal change disease is a kidney disorder that can lead to nephrotic syndrome. Nephrotic syndrome is a group of symptoms that include protein in the urine, low blood protein levels in the blood, high cholesterol levels, high triglyceride levels, and swelling.

What is minimal change disease in children?

Minimal Change Disease (MCD) is a disorder affecting the filtering units of the kidney (glomeruli) that can lead to symptoms associated with Nephrotic Syndrome. It is one of the most common causes of Nephrotic Syndrome in children worldwide and can also be diagnosed in adults.

Why is minimal change disease common in children?

In children, MCD is usually primary (or idiopathic, which means the exact cause is not known). If you have secondary causes for MCD, the disease may occur or be related to: Allergic reactions. Use of certain painkillers called non-steroidal anti-inflammatory drugs (NSAIDs)

Which child is most at risk for minimal change nephrotic syndrome?

Which children are more likely to develop nephrotic syndrome? Children of all ages can develop nephrotic syndrome. But the condition most often affects children who are 2 to 7 years old, particularly boys.

Which pathophysiologic process is associated with minimal change nephropathy in a child?

Interleukin-13 (IL-13) has been implicated in the pathogenesis of MCD. In a study on Chinese children in Singapore, it was shown that IL-13 genetic polymorphisms correlate with the long-term outcome of MCD.

What is the first indication of nephrotic syndrome in children?

You may see swelling around your child’s eyes in the morning. Often, that’s the first sign. As time passes, the swelling may last all day, and you may see swelling in your child’s ankles, feet or belly.

Which of the following is involved in the pathogenesis of minimal change disease?

Interleukin-13 (IL-13) has been implicated in the pathogenesis of MCD.

What causes minimal change disease?

The cause of minimal change disease is not fully known but it is believed to be an immune disorder in which T cells release a cytokine that damages the epithelial foot processes of the glomeruli.

What are the symptoms of minimal change disease?

Signs and symptoms. The clinical signs of minimal change disease are proteinuria (abnormal excretion of proteins, mainly albumin, into the urine), oedema (swelling of soft tissues as a consequence of water retention), weight gain, and hypoalbuminaemia (low serum albumin). These signs are referred to collectively as nephrotic syndrome.

What is the treatment for minimal change disease?

Glucocorticoid therapy is the treatment of choice in minimal change disease (MCD), leading to a complete remission of proteinuria in over 85 to 90 percent of cases.

What is minimal change disorder?

Minimal change disease is a disorder where there is damage to your glomeruli. The disease gets its name because the damage cannot be seen under a regular microscope. It can only be seen under a very powerful microscope called an electron microscope. Minimal change disease is the most common cause of nephrotic syndrome in children.

https://www.youtube.com/watch?v=4Y4PWTXjyEc