Is norvaline a protein?
Is norvaline a protein?
Norvaline is a non-proteinogenic unbranched-chain amino acid. It has previously been reported to be a natural component of an antifungal peptide of Bacillus subtilis. Norvaline and other modified unbranched chain amino acids have received attention because they appear to be incorporated in some recombinant proteins found in E. coli.
Is L-norvaline cytotoxic?
At high concentrations, all amino acids are cytotoxic, and norvaline toxicity could be attributed to protein amino acid mimicry. However, the conclusions of this study have been recently questioned, because the demonstrated l-norvaline toxicity is limited to specific in vitro assays at exceedingly high concentrations.
What is the formula for nornorvaline?
Norvaline (abbreviated as Nva) is an amino acid with the formula CH 3(CH 2) 2CH(NH 2)CO 2H. The compound is an isomer of the more common amino acid valine.
What is the effect of norvaline on cell viability?
Norvaline is known to promote tissue regeneration and muscle growth, and to become a precursor in the penicillin biosynthetic pathway. For mammalian cells an in vitro study showed that l-norvaline decreased cell viability at concentrations as low as 125 μM, and caused necrotic cell death and significant changes to mitochondrial…
