Is Prontosil is a prodrug?

Is Prontosil is a prodrug?

Prontosil is a prodrug; in vivo metabolism converts it into the sulfa drug sulfanilamide, the active antibiotic agent.

Is trimethoprim a prodrug?

In this report we present a prodrug of trimethoprim termed TM-TMP, which is composed of thiomaltose conjugated to trimethoprim, via a self-immolative disulfide linkage.

What does Prontosil treat?

Prontosil, also called sulfamidochrysoidine, trade name of the first synthetic drug used in the treatment of general bacterial infections in humans.

Is trimethoprim bactericidal or bacteriostatic?

When used alone, trimethoprim is bacteriostatic, but it is bactericidal when combined with sulfonamides. Trimethoprim is used in combination with sulfonamides to treat urinary tract infections, prostatic infections, otitis media in children, elimination of Shigella, and treatment of Pneumocystis carinii pneumonia.

What class of drug is trimethoprim?

Trimethoprim is a prescription medicine used to treat the symptoms of bacterial infections. Trimethoprim may be used alone or with other medications. Trimethoprim belongs to a class of drugs called Antibiotics, Other.

Where is Prontosil converted to sulfanilamide which body part?

Prontosil is an azo-dye with the sulfonamide structure. In the human body, prontosil is metabolized into sulfanilamide under the action of cellular enzymes [3], which is shown schematically in Figure 1. Sulfonamides are the first successfully synthesized selectively toxic antimicrobial drugs [4,5].

Is prontosil still used?

Prontosil has been replaced in clinical use by newer sulfonamide drugs, including sulfanilamide, sulfathiazole, sulfamethoxazole, and others.

What is Prontosil used for in humans?

Prontosil was the forerunner of the sulfonamide drugs, which came to be widely used for the treatment of bacterial infections in humans and domestic animals.…. sulfa drug. …effects of the red dye Prontosil on Streptococcus infections in mice.

Does Prontosil kill Streptococcus in mice?

The azo dye prontosil (Fig. 1 A) was identified as an anti-infective agent active against Streptococcal infections in mice. 37 Prontosil exhibited its efficacy only in vivo mouse infection models, with no apparent antibacterial activity against Streptococci in vitro.

What are the different phases available in Prontosil column?

In addition to more typical C8 and C18 phases, ProntoSIL columns are also available in hard to find bonded phases such as C1, amino, DIOL and C30. ProntoSIL is the silica support of BISCHOFF Chromatography. It can be used in normal phase chromatography.

What is the molecular formula of Prontosil?

Prontosil PubChem CID 66895 Structure Find Similar Structures Molecular Formula C12H13N5O2S Synonyms prontosil Sulfamidochrysoidine 103-12-8 Molecular Weight 291.33