Is tianeptine an SSRE?

Is tianeptine an SSRE?

Tianeptine is no longer labelled a Selective Serotonin Reuptake Enhancer (SSRE) antidepressant. Tianeptine has been found to bind to the same allosteric site on the serotonin transporter (SERT) as conventional TCAs.

What is tianeptine sodium powder?

Tianeptine is a prescription drug for depression in some European, Asian, and Latin American countries. Tianeptine is not approved as a prescription drug or dietary supplement in the U.S. Tianeptine is most commonly used for depression.

How long does tianeptine sulfate take to kick in?

Users of online forums report tianeptine sodium and sulfate begins working within 30-60 minutes when taken orally. However, the onset of effects may be faster when taken via other routes of administration.

Is tianeptine sulfate water soluble?

Tianeptine sodium is a water soluble antidepressant effective against anxiety accompanying mood disorders. Its antidepressant and anxiolytic properties and its action on somatic complaints claimed to make the drug particularly suitable for the treatment of the entire range of depressive symptomatology (10,11).

How does SSRE work?

These drugs work by targeting serotonergic and/or noradrenergic and/or dopaminergic neurotransmission with the aim of increasing their synaptic concentrations (Stahl, 2000). Glutamate antagonists represent a novel class of drug currently being tested in refractory depression (Zarate et al., 2006).

What is ZaZa used for?

Tianeptine, ZaZa, Tianna Red — at a gas station near you Tianeptine is an antidepressant that is approved for use in several European countries but not approved in the United States, as Rushton and several UAB co-authors explained in a paper published in the journal Clinical Toxicology in June 2020.

What are the side effects of tianeptine?

The most common adverse effects are nausea, constipation, abdominal pain, headache, dizziness and changes in dreaming. Anticholinergic effects occur less often with tianeptine than with tricyclic agents. Hepatoxicity is rare.

Does tianeptine help with pain?

The best known agonist of the mu opioid receptor is morphine, which is a very effective pain killer but also a drug of abuse. The researchers found that tianeptine also reduces pain but does not result in tolerance or withdrawal like morphine.

What is tianeptine soluble in?

Tianeptine (sodium salt) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of tianeptine (sodium salt) in these solvents is approximately 10, 20, and 30 mg/ml, respectively.

Tianeptine sodium powder is a selective enhancer of serotonin uptake in the brain with no effect on noradrenalin or dopamine uptake. Clinically useful antidepressant. Displays neuroprotective effects against hypoxia in cell culture and against the deleterious effects of cytokines in vivo.

How does tianeptine work to treat depression?

Initial studies found that Tianeptine helped alleviate depressive symptoms by decreasing extracellular level of serotonin, rather than increasing the release of serotonin, like other established antidepressants such as TCA’s and SSRI’s[5].

What are the side effects of tianeptine sulfate?

Side Effects of Tianeptine Sulfate. Side effects include, dizziness, Insomnia, drowsiness, dry mouth, constipation, low blood pressure and addiction. Pregnant and nursing women should not take tianeptine until more studies have been conducted.

What is the generic name for tianeptine?

Tianeptine is officially approved in some Asian, South American and European countries, under brand names such as Stablon, Coaxil and Tanitol [1] [4] [13]. Tianeptine is mainly prescribed to treat major depressive disorder, although recently, it’s been indicated for use with IBS and Asthma [14] [10].