What are examples of cytotoxic drugs?
What are examples of cytotoxic drugs?
Related drugs
- ALLOPURINOL.
- APREPITANT.
- AZATHIOPRINE.
- BLEOMYCIN.
- CARMUSTINE.
- CISPLATIN.
- CYCLOPHOSPHAMIDE.
- DACARBAZINE.
What is meant by cytotoxic drug?
Cytotoxic drugs (sometimes known as antineoplastics) describe a group of medicines that contain chemicals which are toxic to cells, preventing their replication or growth, and so are used to treat cancer. They can also be used to treat a number of other disorders such as rheumatoid arthritis and multiple sclerosis.
What is an example of a chemotherapy drug?
Alkylating agents These drugs will kill cells in all phases of the cell cycle. Some examples of alkylating agents are Chlorambucil, Cyclophosphamide, Cisplatin, and Carboplatin.
What do cytotoxic drugs cause?
Exposure to cytotoxic drugs has been reported to cause increased frequency of chromosome damage in exposed workers. They can cause acute skin, eye, and mucous membrane irritations, as well as nausea, headaches, and dizziness.
Is dexamethasone cytotoxic?
Conclusion: In a bone marrow-derived microenvironment, dexamethasone is five to six times more cytotoxic (on a molar basis) than prednisolone, in agreement with the antiinflammatory activities of these drugs.
Is chloramphenicol cytotoxic?
Chloramphenicol is an old antibiotic that also inhibits mammalian mitochondrial protein synthesis. Our studies demonstrated that chloramphenicol is highly cytotoxic to myeloma cells, acting in a dose- and time-dependent manner.
What are the classification of cytotoxic drugs?
They are broadly classified as alkylating agents, antimetabolites, natural products, and miscellaneous drugs.
Is Cyclosporine a cytotoxic drug?
For the purposes of this review we have adopted the classification described in theBritish National Formulary defining cyclosporine as an ISD; cyclophosphamide, vincristine, chlorambucil, and methotrexate as CDs; and azathioprine (and its active metabolite 6-mercaptopurine) and mycophenolate mofetil as “cytotoxic …
What are cytotoxic drugs?
Cytotoxic drugs include any drug that inhibits or prevents the function of cells. Cytotoxic drugs include drugs used to treat cancer and in some cases, to treat certain skin conditions (e.g., psoriasis).
Why are cancer cells more sensitive to cytotoxic drugs?
But because cancer cells often divide markedly faster than normal cells, they are particularly sensitive to cytostatics. The effects on normal cells are less pronounced and healthy cells also recover faster. The role of cytotoxic drugs in cancer therapy has decreased slightly with the development of drug therapy.
What is the difference between cytotoxic and cytostatic drugs?
In this sense, a cytotoxic agent may be differentiated from one that is cytostatic. A cytostatic medication would, in contrast, inhibit cell division and growth but would not result in cell death directly. Cytotoxic drugs work by interrupting cells at particular places in the growth cycle.
What is the mechanism of action of cytotoxic agents?
Mechanism of Action. Cytotoxic agents can kill cells in several ways. They may harm the cell so that its cell membrane is weakened and the cell explodes (lysis) or they may interfere with cell division so the cell stops growing and dividing.
