What are glycoprotein IIb IIIa inhibitors used for?

What are glycoprotein IIb IIIa inhibitors used for?

GP IIb/IIIa inhibitors are used for the management of acute coronary syndrome such as: Unstable angina (chest discomfort caused by poor blood supply to the heart muscle) Non-ST elevation myocardial infarction (heart attack) that requires percutaneous coronary interventions within 24 hours.

Which drugs does not block by GP IIb IIIa receptors?

Eptifibatide and tirofiban, also known as “small molecule agents,” do not induce immune response and have lower affinity for the GP IIb/IIIa receptor than abciximab.

What is GP 2b and 3a antagonist?

Glycoprotein IIb/IIIa receptor antagonists include abciximab, eptifibatide, and tirofiban. Glycoprotein IIb/IIIa antagonists prevent the binding of fibrinogen, thereby blocking platelet aggregation.

What kind of drug is Integrilin?

Integrilin (eptifibatide) injection is a platelet aggregation inhibitor indicated for treatment of acute coronary syndrome (ACS) managed medically or with percutaneous coronary intervention (PCI), and treatment of patients undergoing PCI (including intracoronary stenting).

Which is an ADP receptor antagonist?

Adenosine-diphosphate (ADP) receptor antagonists like clopidogrel, ticlopidine, prasugrel and ticagrelor impair platelet aggregation and fibrinogen-mediated platelet cross-linking and may be effective in preventing CVD.

How do glycoproteins help viruses?

The surface glycoproteins of an enveloped virus attach the virion to a target host cell by properly interacting with a cellular receptor [22]. Structural biological analysis of viral envelope glycoproteins reveals that viruses have wide range of folds to facilitate their attachment with proper host receptors.

How does Integrilin work?

The active substance in Integrilin, eptifibatide, stops the platelets aggregating by blocking a protein called glycoprotein IIb/III on their surface that helps make them sticky. Integrilin greatly reduces the risk of a blood clot forming and helps prevent another heart attack.

When do you use Integrilin?

Integrilin is used to prevent blood clots or heart attack in people with severe chest pain or other conditions, and in those who are undergoing a procedure called angioplasty (to open blocked arteries). Integrilin may also be used for purposes not listed in this medication guide.

How do glycoprotein IIb/IIIa inhibitors work?

Use Glycoprotein IIb/IIIa inhibitors are frequently used during percutaneous coronary intervention (angioplasty with or without intracoronary stent placement). They work by preventing platelet aggregation and thrombus formation. They do so by inhibition of the GpIIb/IIIa receptor on the surface of the platelets.

What is the structure of the GP IIb/IIIa receptor?

In particular, the GP IIb/IIIa receptor is a heterodimer consisting of the alpha IIb and beta 3 -subunits. By competing with fibrinogen and von Willebrand factor (vWF) for GP IIb/IIIa binding, GP IIb/IIIa antagonists interfere with platelet cross-linking and platelet-derived thrombus formation.

What are the ACS and PCI guidelines for use of GP IIb/IIIa receptor inhibitors?

ACS and PCI guidelines for use of GP IIb/IIIa receptor inhibitors are summarized in Table 1. The primary adverse effect to GP IIb/IIIa receptor antagonists is bleeding. The risk of bleeding complications has limited the use of GP IIb/IIIa receptor antagonists, which are now reserved for high thrombotic risk settings.

What does GP IIb/IIIa stand for?

Glycoprotein (GP) IIb/IIIa antagonists are potent inhibitors of platelet aggregation that provide marked protection from ischemic events in patients undergoing percutaneous coronary intervention (PCI). 1,2 Abciximab, the prototypic GP IIb/IIIa inhibitor, has been studied in >8000 patients undergoing…