What are Ly6C monocytes?
What are Ly6C monocytes?
Ly6Clow monocytes, also known as patrolling monocytes, survey the vasculature by constantly crawling along the lumen of the vasculature and are involved with early responses to inflammation and tissue repair. These alternative monocytes express high levels of CX3CR1 and low levels of CCR2 (CX3CR1hiCCR2low).
What does Ly6C stand for?
Official Symbol Ly6c1provided by MGI Official Full Name lymphocyte antigen 6 complex, locus C1provided by MGI Primary source MGI:MGI:96882 See related Ensembl:ENSMUSG00000079018 Gene type protein coding RefSeq status VALIDATED Organism Mus musculus Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; …
Can inflammation cause high monocytes?
The main causes of high monocytes (monocytosis) are chronic inflammation and infections.
Do T cells express Ly6C?
Ly6C is a murine cell-surface antigen expressed by plasma cells, subsets of myeloid cells and many T cells, including memory T cells.
Do monocytes express Ly6C?
In contrast, Ly6CLo-neg and Ly6CHi monocytes/macrophages differentially express various phenotypic markers, which could be indicative of distinct maturation stages between these cell populations.
What is lyly6c Hi monocytes?
Ly6C hi Monocytes and their MoMF Descendants Mediate Neutrophil Apoptosis and Clearance, Respectively. Once neutrophils exerted their function, they launch apoptotic pathways that ensure clearance of ROS-producing neutrophils from injured tissue to avoid excessive inflammation and oxidative damage (29, 56).
What is ly-6c + CD62L?
The first subset is Ly-6C + CD62L/L-Selectin + and expresses high levels of CCR2 and low levels of CX3CR1. This subset is commonly referred to as Ly-6C + monocytes or inflammatory monocytes as these cells are rapidly recruited to sites of inflammation.
How are circulating monocytes characterized based on differential expression of ly-6c?
Among these cells, two subsets of circulating monocytes have been characterized based on the differential expression of Ly-6C, CCR2, CD62L/L-Selectin, and CX3CR1. The first subset is Ly-6C + CD62L/L-Selectin + and expresses high levels of CCR2 and low levels of CX3CR1.
Do liver-infiltrating Ly6C Hi monocytes and their momf descendants share a task division?
Collectively, our findings establish a phase-dependent task division between liver-infiltrating Ly6C hi monocytes and their MoMF descendants with the former regulating innate immune functions and cell survival of neutrophils and the later neutrophil clearance.
