What are the benefits of B12?
What are the benefits of B12?
What is vitamin B12 and what does it do? Vitamin B12 is a nutrient that helps keep your body’s blood and nerve cells healthy and helps make DNA, the genetic material in all of your cells. Vitamin B12 also helps prevent megaloblastic anemia, a blood condition that makes people tired and weak.
Can B12 too high?
An abnormally high vitamin B-12 status is anything over 900 pg/mL. This result may suggest liver or kidney problems, diabetes, or certain forms of leukemia.
Is low B12 common?
Even though the vitamin is found in many foods, B12 insufficiency and deficiency are relatively common. This is often due to limited dietary intake, malabsorption, certain medical conditions, or the use of B12-depleting medications ( 2 , 3 , 4 ).
What does it mean if your cobalamin is high?
Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin.
What is the function of methylcobalamin and cyanocobalamin in vitamin B12?
The vitamin activity is as a coenzyme, meaning that its presence is required for some enzyme-catalyzed reactions. cyanocobalamin, the adenosyl ligand in vitamin B 12 is replaced by cyanide. hydroxocobalamin, the adenosyl ligand in vitamin B 12 is replaced by hydroxide. methylcobalamin , the adenosyl ligand in vitamin B 12 is replaced by methyl.
Does cobalamin deficiency cause gastrointestinal disease?
As all cells in the body require cobalamin for single carbon metabolism, it has been hypothesized that cobalamin deficiency may actually contribute to the clinical signs and manifestations of gastrointestinal disease in some patients.
What is the recommended protocol and dose for cobalamin?
We currently recommend either oral or parenteral cobalamin supplementation and the recommended protocol and dose for each route is as below. For oral cobalamin supplementation: Protocol: daily administration for total 12 weeks and re-check serum cobalamin concentration one week after finishing supplementation.
