What are the contraindications of aminoglycosides?
What are the contraindications of aminoglycosides?
Warnings and Precautions Are allergic to sulfites (often found in certain wines and dried fruits) Have kidney or hearing problems, including problems with balance and uncontrollable eye movements. Have a disorder affecting the nerves and muscles, like multiple sclerosis or myasthenia gravis. Are 65 years of age or …
What drugs interact with aminoglycosides?
Trimethaphan (1.5 X 10(-2) mmol X l-1) interacts with the following aminoglycoside antibiotics: gentamicin (0.04), streptomycin (0.05), netilmicin (0.06), amikacin (0.11), sisomicin (0.14), kanamycin (0.17), tobramycin (0.18) and dibekacin (0.21 mmol X l-1) to produce a complete neuromuscular blockade.
What are the three main side effects of aminoglycosides?
The major side effects of aminoglycosides are kidney injury, hearing impairment and vestibular toxicity.
Do aminoglycosides cover Pseudomonas?
The aminoglycosides tobramycin, gentamicin, and amikacin are commonly used to treat hospital-acquired infections caused by Pseudomonas aeruginosa. These infections generally require treatment with a combination of antimicrobials in order to achieve a greater bactericidal effect and reduce the levels of resistance1.
Why is aminoglycoside contraindicated in myasthenia gravis?
Aminoglycosides should be avoided in patients with myasthenia gravis because of the risk of prolonged neuromuscular blockade.
What class is Clindamycin?
Clindamycin is in a class of medications called lincomycin antibiotics. It works by slowing or stopping the growth of bacteria.
What type of bacteria do aminoglycosides cover?
Aminoglycosides are a class of antibiotics used mainly in the treatment of aerobic gram-negative bacilli infections, although they are also effective against other bacteria including Staphylococci and Mycobacterium tuberculosis.
What medications should I avoid with myasthenia gravis?
Drugs to avoid Commonly-used medications like ciprofloxacin or certain other antibiotics, beta-blockers like propranolol, calcium channel blockers, Botox, muscle relaxants, lithium, magnesium, verapamil and more, can worsen the symptoms of myasthenia gravis.
Why are beta blockers contraindicated in myasthenia gravis?
Some medications, for instance various antibiotics or cardiovascular drugs (beta blockers, calcium channel blockers), that directly impair neuromuscular transmission due to different pre- or postsynaptic or combined mechanisms, usually cause transient worsening of symptoms in patients with a previously diagnosed …
What are the contraindications of clindamycin?
Who should not take CLINDAMYCIN HCL?
- diarrhea from an infection with Clostridium difficile bacteria.
- myasthenia gravis, a skeletal muscle disorder.
- Crohn’s disease.
- ulcerative colitis, an inflammatory condition of the intestines.
- severe liver disease.
- blood in the bowel movement.
- severe renal impairment.
What are the contraindications for aminoglycosides?
There are very few absolute contraindications to aminoglycosides; however, they should be used with caution with patients with pre-existing hearing, vestibular and renal impairment. 2 Table 1. Indications for parenteral aminoglycosides 2
What are the different types of aminoglycoside drugs?
There are several drugs within the aminoglycoside class, including gentamicin, tobramycin, amikacin, neomycin, plazomicin, and streptomycin, and FDA-approved indications vary between the for these individual aminoglycosides.
What are the clinical toxicities of aminoglycosides?
The significant clinical toxicities of aminoglycosides are ototoxicity, nephrotoxicity and less often neuromuscular toxicity.
Can aminoglycosides be given orally?
Because aminoglycosides are normally used to treat serious infections, they are typically administered into the veins of the body (intravenously, or IV). However, some aminoglycosides can be taken orally, or as ear or eye drops. Examples of aminoglycosides include: Gentamicin (generic version is IV only)
