What are the different types of familial hypercholesterolemia?
What are the different types of familial hypercholesterolemia?
Familial Hypercholesterolemia
- autosomal dominant hypercholesterolemia.
- FH.
- hyperlipoproteinemia, type IIA.
- LDLR-related familial hypercholesterolemia, autosomal dominant.
- APOB-related familial hypercholesterolemia, autosomal dominant.
- PCSK9-related familial hypercholesterolemia, autosomal dominant.
What is the most common cause of familial hypercholesterolemia?
Mutations in the APOB, LDLR, LDLRAP1, or PCSK9 gene cause familial hypercholesterolemia. Changes in the LDLR gene are the most common cause of this condition. The LDLR gene provides instructions for making a protein called a low-density lipoprotein receptor.
How do you know if you have familial hypercholesterolemia?
How do I know if I have familial hypercholesterolemia?
- Bumps or lumps around your knees, knuckles, or elbows.
- Swollen or painful Achilles tendon.
- Yellowish areas around your eyes.
- A whitish gray color in the shape of a half-moon on the outside of your cornea.
What does familial hypercholesterolemia do to the body?
Familial hypercholesterolemia affects the way the body processes cholesterol. As a result, people with familial hypercholesterolemia have a higher risk of heart disease and a greater risk of early heart attack. The genetic changes that cause familial hypercholesterolemia are inherited.
Is familial hypercholesterolemia the same as hyperlipidemia?
Familial hypercholesterolemia (FH), also known as familial hyperlipoproteinemia type 2 or Fredrickson class 2a hyperlipidemia, is an autosomal dominant-inherited genetic disorder that leads to elevated blood cholesterol levels.
Can hyperlipidemia be hereditary?
For some people, high blood levels of cholesterol come from a diet that’s high in saturated fat and animal products, but for others, high cholesterol is genetic: It runs in the family. In addition to getting cholesterol from dietary sources like meat and dairy, our bodies make cholesterol, too.
How can I lower my familial cholesterol naturally?
Cutting back on foods rich in cholesterol and saturated fat, such as red meat and full-fat dairy products, helps lower LDL. So does eating fish, whole grains, vegetables, and vegetable oils — all good sources of unsaturated fats.
Does familial hypercholesterolemia affect triglycerides?
Triglyceride levels are usually two to three times higher than normal which distinguishes this condition from Familial Hypercholesterolaemia (FH) where only cholesterol, specifically LDL cholesterol is raised.
How much is cholesterol hereditary?
When It’s in Your Genes Almost 1 in 3 adults has high cholesterol. Only 1 in 300 people has familial hypercholesterolemia. Anyone who has one of the 1,500 possible gene variants that cause the condition has a 50% chance of passing that gene on to their children.
How do you reverse familial hypercholesterolemia?
The most common treatment for FH is statin drug therapy. Statin drugs work by blocking an enzyme that produces cholesterol in the liver and increases your body’s ability to remove cholesterol from the blood. They can lower your LDL cholesterol levels by 50 percent or more.
