What are the side effects of Zosyn?

What are the side effects of Zosyn?

Nausea, constipation, diarrhea, headache, or trouble sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

When should you hold Zosyn?

Single-dose vials should be used immediately after reconstitution. Discard any unused portion after 24 hours if stored at room temperature, or after 48 hours if stored at refrigerated temperature. IV bags must be used within 24 hours at room temperature and up to one week if refrigerated.

Can Zosyn cause confusion?

Tell your doctor if you have serious side effects of Zosyn including muscle cramps or spasms, swelling of the arms/legs/hands/feet, easy bruising or bleeding, chest pain, confusion, new signs of infection (such as fever, persistent sore throat), severe abdominal or stomach pain, slow/fast/irregular heartbeat.

Is Zosyn hard on the kidneys?

If alternative treatment options are inadequate or unavailable, monitor renal function during treatment with Zosyn. Precautions section stating that combined use of these two drugs may be associated with an increased incidence of acute kidney injury.

What medications interact with Zosyn?

ZOSYN®Drug Interactions (piperacillin, tazobactam)

• 7.1 Aminoglycosides. Piperacillin may inactivate aminoglycosides by converting them to microbiologically inert amides.
• 7.2 Probenecid.
• 7.3 Vancomycin.
• 7.4 Anticoagulants.
• 7.5 Vecuronium.
• 7.6 Methotrexate.
• 7.7 Effects on Laboratory Tests.

Does Zosyn treat sepsis?

Broad-spectrum agents, such as piperacillin-tazobactam (Zosyn) and vancomycin, are commonly used for empirical antibiotic coverage in suspected early sepsis and critically ill patients.

Can Zosyn cause thrombocytopenia?

Highlights. The first case of piperacillin-induced thrombocytopenia is reported in a dual heart and kidney transplant patient taking Zosyn. Four previous studies report patients with Zosyn -induced thrombocytopenia per history.

How long does Zosyn stay in your system?

Tazobactam is metabolized to a single metabolite that lacks pharmacological and antibacterial activities. Following single or multiple ZOSYN doses to healthy subjects, the plasma half-life of piperacillin and of tazobactam ranged from 0.7 to 1.2 hours and was unaffected by dose or duration of infusion.

Does zosyn affect creatinine?

Piperacillin-tazobactam may increase serum creatinine due to a reduction in tubular creatinine secretion, caused by inhibition of the organic anion transporter. This causes “pseudo-nephrotoxicity” – increase serum creatinine, without impaired renal function or true renal injury.

Is Pipzo renal safe?

Tazobactam/piperacillin (TAZ/PIPC) is a combination antibiotic frequently used to treat pneumonia. It has recently been reported that TAZ/PIPC worsens renal function in patients with existing renal impairment.

Does Zpack treat sepsis?

In conclusion, azithromycin was associated with a beneficial effect on 28-day ICU-free days in severe sepsis patients, including patients without pneumonia.

What are the possible adverse effects of Zosyn?

However, in 3.2% of the patients treated worldwide, ZOSYN was discontinued because of adverse events primarily involving the skin (1.3%), including rash and pruritus; the gastrointestinal system (0.9%), including diarrhea, nausea, and vomiting; and allergic reactions (0.5%). Table 3: Adverse Reactions from ZOSYN Monotherapy Clinical Trials

What are the side effects of Zosyn (duloxetine)?

Common side effects of Zosyn include: injection site reactions like swelling, redness, pain, soreness or. irritation; dizziness, agitation, trouble sleeping (insomnia), nausea, vomiting, stomach pain or upset, diarrhea, constipation, headache, runny nose, anxiety, skin rash or itching, or vaginal discharge or itching.

When should Zosyn be reduced in patients with renal impairment?

In patients with renal impairment (creatinine clearance ≤ 40 mL/min) and dialysis patients (hemodialysis and CAPD), the intravenous dose of Zosyn should be reduced to the degree of actual renal function impairment. The recommended daily doses of Zosyn for patients with renal impairment are as follows:

What are the side effects of general anesthesia in senior patients?

Side Effects of General Anesthesia in Senior Patients. There’s always a risk anytime surgery is involved. However, for older relatively healthy senior patients (60 years and older) these risks can include cognitive impairment after undergoing anesthesia.