What are the types of dissolution apparatus?
What are the types of dissolution apparatus?
Currently, there are seven different types of dissolution apparatus defined in the United States Pharmacopeia (USP)-basket type, paddle type, reciprocating cylinder, flow through cell, paddle over disc, rotating cylinder, and reciprocating disc.
What is Type 1 dissolution apparatus?
USP Dissolution Apparatus 1 – Basket (37 °C ± 0.5°C ) USP Dissolution Apparatus 2 – Paddle (37°C ± 0.5°C) USP Dissolution Apparatus 3 – Reciprocating Cylinder (37 °C ± 0.5°C) USP Dissolution Apparatus 4 – Flow-Through Cell (37 °C ± 0.5°C)
What is USP apparatus?
USP Apparatus 1 (basket) and 2 (paddle) were introduced in the 1970s for the purpose of providing a platform to evaluate the in vitro performance of dosage forms using standardized conditions.
What is the principle of dissolution apparatus?
The principle function of the dissolution test may be summarised as follows: Optimisation of therapeutic effectiveness during product development and stability assessment. Routine assessment of production quality to ensure uniformity between production lots.
Why do we use 900 ml in Dissolution apparatus?
Most likely, the volume was lowered to 900mL to account for volume displacement from the product and stirring shaft. This gives some wiggle room in the test, so that the vessel doesn’t spill over during the dissolution. At these volumes, you can achieve success with most products as well.
What is Q value in dissolution?
Q, as it relates to dissolution is commonly used in the USP for immediate release and delayed release dosage forms. The quantity of Q is the amount of dissolved active ingredient specified in the individual monograph expressed as a percentage of the labeled content.
How do you use dissolution apparatus?
Warm the dissolution medium to 36.5° to 37.5°. Place one dosage unit in the apparatus, cover the vessel and operate the apparatus at the specified rate. After 2 hours of operation in the acid medium, withdraw an aliquot of the liquid and proceed immediately as directed under Buffer stage.
What is D value in dissolution?
Buffer stage The quantity, D, is the specified total amount of active substance dissolved in both the acid and buffer stages, expressed as a percentage of the labeled content.
Why is 500 ml dissolution media?
At 500mL, there is ample volume to have media above the paddle or basket and preserve hydrodynamics in the vessel. If you do need more volume or less volume, there are other vessel sizes available and other approaches you can use.
