What causes Chondrogenesis?
What causes Chondrogenesis?
Chondrification. Chondrogenesis is initiated by a response to an extracellular matrix-mediated interaction either via a basal lamina or via an ectodermal–mesenchymal interaction (Syftestad and Caplan, 1984; Hall, 1988).
What are the stages of Chondrogenesis?
ESC chondrogenesis can be characterized by five main stages of cellular, extracellular and molecular events: (1) Condensation of differentiated ESCs, (2) Differentiation into chondrocytes and fibril scaffold formation, (3) ECM deposition and cartilage formation, (4) Hypertrophy and degradation of cartilage, and (5) …
What is chondrofication or chondrogenesis?
Chondrification (also known as chondrogenesis) is the process by which cartilage is formed from condensed mesenchyme tissue, which differentiates into chondrocytes and begins secreting the molecules that form the extracellular matrix. Early in fetal development, the greater part of the skeleton is cartilaginous.
What is chondrocyte differentiation?
Chondrocyte and osteoblast are two primary cell types in the skeletal systems that are differentiated from common mesenchymal progenitors. It is shown that Wnt signaling can regulate chondrocyte and osteoblast differentiation of the chondroosseous progenitor cells.
What is Chondrogenic tumor?
Chondrogenic tumors are the second largest group of bone tumors. Their histologic pattern suggests a relationship to hyaline cartilage. Exostoses, or osteochondromas, represent about 1/3 of chondrogenic lesions.
What is the function of Perichondrium?
The fibrous nature of perichondrium tissue allows blood flow to easily pass through your body. This steady blood flow helps distribute nutrients necessary to strengthen and nourish your cartilage. Fibrous perichondrium tissue also allows oxygen and nutrients to flow without obstruction.
What soluble factors are involved in Chondrogenesis?
MSC chondrogenic potential Elements including soluble factors such as growth factors, cytokines, hormones, various intracellular signaling pathways and transcription factors, environmental factors such as mechanical loading and oxygen levels, and seeding density all affect chondrogenic differentiation of MSCs.
What is Chondrogenic medium?
MesenCult™-ACF Chondrogenic Differentiation Medium is animal component-free (ACF) and specifically formulated for the in vitro differentiation of human mesenchymal stromal cells (MSCs; also known as mesencyhymal stem cells) into chondrogenic lineage cells, including chondrocytes.
What is chondrocyte proliferation?
During this process, a cartilage template is formed in which chondrocytes proliferate and differentiate into hypertrophic chondrocytes and are gradually replaced by bone. The coordinated proliferation and differentiation of chondrocytes ensures the continuous elongation of the epiphyseal growth plates.
Can chondrosarcoma be cured?
Chondrosarcoma treatment often involves surgery to remove the cancer. Other treatments might be recommended in certain situations. Which options are best for you depends on where your cancer is located, how quickly it’s growing, whether it has grown to involve other structures, your overall health and your preferences.
What is the function of the chondrogenic layer?
The inner chondrogenic layer consists of chondroblasts, a type of cell that plays an important role in the formation of new cartilage.
What is the pathophysiology of chondrogenesis?
Chondrogenesis, the fate of most skeletogenic cells, results in the construction of a multitude of cartilage anlagen, which altogether constitute the primary skeleton of the vertebrate embryo (Fig. 8.3 A). This process occurs in two steps: precartilaginous condensation and chondrocyte early differentiation ( Fig. 8.3 B).
What is chondrogenic cartilage?
chondrogenic adjective Referring to the formation of cartilage; cartilage forming. Segen’s Medical Dictionary. © 2012 Farlex, Inc.
How does ultrasound promote chondrogenic progenitor cell migration?
For chondrogenic differentiation, the cells start aggregating within 2-3 days under chondrogenic differentiating medium. Low-intensity pulsed ultrasound promotes chondrogenic progenitor cell migration via focal adhesion kinase pathway.
Does ADAMTS7 inhibit chondrocyte differentiation?
Further experimentation has established that the chondrogenic inhibitory effect of ADAMTS7 depends specifically on the four C-terminal thrombospondin motifs [31]. Both parathyroid hormone-related protein (PTHrP) and Indian hedgehog protein (IHH) are known regulators of chondrocyte differentiation.
