What causes pseudoexfoliation of the lens capsule?

What causes pseudoexfoliation of the lens capsule?

Pseudoexfoliation (PEX) syndrome is a well-recognized late-onset disease caused by a generalized fibrillopathy. It is linked to a broad spectrum of ocular complications including glaucoma and perioperative problems during cataract surgery.

What is pseudo exfoliation syndrome?

Pseudoexfoliation syndrome is a condition where a snowflake-like substance accumulates on the structures within the eye. This substance can often be seen on the lens and iris.

What is the treatment for Pseudoexfoliation syndrome?

In addition, as with all glaucomas, the treatment for pseudoexfoliation glaucoma is to lower the eye pressure. Unfortunately, sometimes medications will fail to control the eye pressure, although laser can be very effective.

How is pseudoexfoliation diagnosed?

Although the diagnosis of pseudoexfoliation syndrome (PXS) is made by observation of pseudoexfoliation material (PXM) deposited on the anterior lens capsule, there are several additional signs related to pigment dispersion that are often present both in eyes with PXS and fellow eyes in unilateral cases.

Can Pseudoexfoliation be cured?

Pseudoexfoliation is the most common cause of secondary glaucoma worldwide and can be difficult to treat. MicroPulse laser trabeculoplasty is an effective treatment that is safe and can be repeated as necessary.

Is Pseudoexfoliation syndrome bilateral?

Conclusions These subclinical alterations of contralateral eyes in clinically so-called unilateral PEX syndrome support the concept that PEX syndrome is a generalized basically bilateral disorder with a clinically marked asymmetric manifestation.

Can pseudoexfoliation be cured?

Is pseudoexfoliation a type of glaucoma?

Glaucoma develops in some patients with a condition called exfoliation syndrome. Also known as pseudoexfoliation, it is caused by the abnormal accumulation of protein in the drainage system and other structures of the eye. This is a type of open-angle glaucoma with unique characteristics and physical findings.

What is Pseudoexfoliation material?

Pseudoexfoliation syndrome (PXF/PEX) is a systemic condition characterized by the deposition of white dandruff-like material, called exfoliation material, within the anterior segment of the eye and other organs such as the heart, lungs and kidneys.

Is Pseudoexfoliation glaucoma bilateral?

PDS is more common in younger, myopic patients, and is often bilateral. The pattern of iris transillumination and angle pigmentation is different (see section Pigmentary Glaucoma).

How does Pseudoexfoliation cause glaucoma?

The accumulation of pseudoexfoliative material in the extracellular matrix of tissues results in altered metabolism and hence disturbed structure and function. The trabecular meshwork becomes clogged resulting in reduced aqueous outflow, raised IOP and secondary glaucoma.

What is Pseudoexfoliation syndrome?

Pseudoexfoliation syndrome (PXF) is an age-related systemic microfibrillopathy that targets ocular tissues through the gradual deposition of fibrillary residue from the lens and iris pigment epithelium, mainly on the lens capsule, ciliary body, zonules, corneal endothelium and iris.

What is the prognosis of Pseudoexfoliation of the lens capsule?

Patients with pseudoexfoliation of lens capsuleremain asymptomatic until an advanced glaucoma develops.The patient presents with a fine, flaky material on the anterior lens capsule at the pupillary margin. Over time, this coalesces into a characteristic “bulls-eye” pattern seen in pseudoexfoliation.

What is the pathophysiology of exfoliation syndrome?

Disease. Exfoliation (pseudoexfoliation) Syndrome is characterized by the fibrillar deposits in the anterior segment of the eye. The deposits have been found on and in the subconjunctival tissue, pupillary margin, ciliary epithelium, lens epithelium, lens capsule, iris pigment epithelium, trabecular meshwork,cornea,zonules, orbital soft tissues,…

What is the pathophysiology of pseudoexfoliative glaucoma?

Both genetic and environmental factors may play a role in its pathogenesis. It is commonly seen in older individuals and within certain ethnicities. This condition may present unilaterally and bilaterally and is known to be a major risk factor for secondary open angle glaucoma. Pseudoexfoliative glaucoma is seen in up to 50% of eyes with PXF.