What cells does adenovirus infect?

What cells does adenovirus infect?

Currently, about 110 human adenovirus (HAdV) types and genotypes are known and classified into seven species (A-G). AdVs infect the respiratory organs, the eyes, the kidney, the gastrointestinal tract and blood cells. On a population scale, AdVs emerge unpredictable, and can cause human epidemics.

Can adenovirus infect dividing cells?

Adenoviruses and Adeno-Associated Viruses (AAVs) are two types of viral vectors used for gene delivery. Both of these recombinant viral systems have the ability to infect a broad range of hosts, including dividing and non-dividing cells, without integrating with the host genome.

How does adenovirus affect cells?

Host cells differ in permissivity for adenovirus types (Table 67-2). In permissive cells, the virus multiplies productively and kills the host cell. Other cells are semipermissive, allowing replication at low efficiency, whereas in still others replication is blocked and the infection is abortive.

What cells does adenovirus target?

Replication-defective adenoviruses are being developed as vaccine vectors, and viruses that target receptors expressed on dendritic cells (90) (including CD80/86 and CD46) may prove useful in eliciting strong immune responses.

How does adenovirus cause infection?

Adenovirus can spread through droplets when someone with an infection coughs or sneezes. Fecal material (poop) can spread the infection via contaminated water, dirty diapers, and poor hand washing. Outbreaks of pharyngoconjunctival fever at summer camps are linked to contaminated water in swimming pools and lakes.

How does adenovirus cause disease?

Fluid from the nose, mouth, throat, and lungs (respiratory tract) can contain the virus. Respiratory infections are spread when someone with the virus coughs or sneezes on another person. It can also be spread by touching an object that is contaminated by the virus.

Can retrovirus infect non-dividing cells?

The dependence of retroviral replication on cell proliferation was described as early as 1958, although different classes of retroviruses are able to infect non-dividing cells with different efficiencies.

What types of cells can a virus infect?

Viruses infect all forms of organisms including bacteria, archaea, fungi, plants, and animals. Living things grow, metabolize, and reproduce. Viruses replicate, but to do so, they are entirely dependent on their host cells.

How does the adenovirus use protein receptors to enter the cell?

What are two functions of the proteins receptors covering cell membrane? Protein receptors on the cell membranes monitor what goes in and out. How does the adenovirus use protein receptors to enter the cell? The adenovirus has evolved to make its own key which matches and locks to the cells key to get inside the cell.

What happens to adenovirus vector?

Adenovirus vectors can be replication-defective; certain essential viral genes are deleted and replaced by a cassette that expresses a foreign therapeutic gene. Such vectors are used for gene therapy, as vaccines, and for cancer therapy. Replication-competent (oncolytic) vectors are employed for cancer gene therapy.

What type of virus is adenovirus?

Adenoviruses are medium-sized (90-100 nm), non-enveloped icosohedral viruses with double-stranded DNA. More than 50 types of immunologically distinct adenoviruses can cause infections in humans.

Is adenovirus infection contagious?

Adenovirus infections are most contagious during the first few days of symptoms. Some people, especially those with weakened immune systems, can carry the virus in their tonsils, adenoids, or intestines for weeks or longer. These people might not have any symptoms, but are still be able to spread the virus to others.