What class antiarrhythmic is amiodarone?
What class antiarrhythmic is amiodarone?
Although amiodarone is considered a class III anti-arrhythmic agent, it also has class I, II, IV actions, making it a unique and effective anti-arrhythmic agent.
How does amiodarone stop ventricular fibrillation?
The major effect of chronic amiodarone therapy is an inhibition of outward potassium currents (Vaughan-Williams class III effect) resulting in a prolongation of action potential duration (APD), not only in atrial and ventricular muscles but also in the SA and AV nodes.
Does amiodarone lower heart rate?
Amiodarone produced a lower heart rate than placebo at all exercise levels (p<0.0001 for all). VO2 was similar in both groups whereas O2 pulse was higher in the amiodarone group at all exercise levels.
What are the side effects of amiodarone 200 mg?
The most common side effects that can occur with amiodarone oral tablet include:
- nausea.
- vomiting.
- fatigue.
- tremor.
- lack of coordination.
- constipation.
- insomnia.
- headache.
How does amiodarone work and how does it work?
Amiodarone works by prolonging the duration of the action potential and the refractory period. This, in effect, minimizes how often the electrical system of the heart can zap the heart muscle into a beat.
How do you mix amiodarone for IV infusion?
PREPARE: IV Infusion: First rapid loading dose infusion: Add 150 mg (3 mL) amiodarone to 100 mL D5W to yield 1.5 mg/mL. Second infusion during first 24 h (slow loading dose and maintenance infusion): Add 900 mg (18 mL) amiodarone to 500 mL D5W to yield 1.8 mg/mL.
What is the molecular weight of amiodarone hydrochloride?
Amiodarone hydrochloride PubChem CID 441325 Synonyms Amiodarone hydrochloride 19774-82-4 Amio Molecular Weight 681.8 Parent Compound CID 2157 (Amiodarone) Component Compounds CID 313 (Hydrochloric acid) CID 2157 (Am
What are the possible side effects of IV amiodarone?
IV amiodarone may cause acute liver injury within one day of infusion. Nausea, anorexia, and constipation are the most common gastrointestinal side effects. Neurologic toxicity can occur in up to 27.5% of patients, ranging from cognitive impairment to peripheral neuropathy, ataxia, and in some rare cases, quadriplegia.
