What classification is Cinacalcet?

What classification is Cinacalcet?

Cinacalcet is in a class of medications called calcimimetics. It works by signaling the body to produce less parathyroid hormone in order to decrease the amount of calcium in the blood.

What is the medicine Cinacalcet used for?

Cinacalcet is used to treat hyperparathyroidism in patients with chronic kidney disease who are on dialysis. Hyperparathyroidism is a condition that is caused when the parathyroid glands located in the neck make too much parathyroid hormone (PTH).

What drug class is Sensipar?

Cinacalcet (Sensipar) is in a drug class called calcimimetics. It lowers the amount of parathyroid hormone and calcium in your body.

What are calcimimetic drugs?

Calcimimetics are a group of drugs that are allosteric activators of the calcium-sensing receptor, thereby enhancing signaling and decreasing PTH release independent of vitamin D.

What is another name for cinacalcet?

Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.

How is cinacalcet administered?

The recommended starting oral dose of Sensipar is 30 mg twice daily. The dose of Sensipar should be titrated every 2 to 4 weeks through sequential doses of 30 mg twice daily, 60 mg twice daily, and 90 mg twice daily, and 90 mg 3 or 4 times daily as necessary to normalize serum calcium levels.

Why is cinacalcet used in CKD?

Cinacalcet hydrochloride (Amgen, Thousand Oaks, CA, United States) is a type II calcimimetic that increases the sensitivity to extracellular calcium of the calcium-sensing receptor (CaR) located in chief cells of parathyroid gland, thereby reducing PTH synthesis and release [4].

What is the difference between sensipar and cinacalcet?

Sensipar is a drug manufactured by Amgen. Sensipar is the trade name, the generic name for this drug is “Cinacalcet”. Sensipar comes as a small pill in three strengths (30mg, 60mg, and 90mg). This drug was designed for the treatment of SECONDARY hyperparathyroidism.

What is cinacalcet mechanism of action?

Mechanism of Action Cinacalcet is an oral calcimimetic agent that increases the sensitivity of the calcium-sensing receptor to activation by extracellular calcium. The calcium-sensing receptors on the surface of parathyroid gland cells also regulate parathyroid hormone (PTH) secretion.

What is the medication cinacalcet used for?

CINACALCET is used to treat patients with chronic kidney disease who are on dialysis. It is also used to treat high levels of calcium in the blood of patients with certain parathyroid gland problems. The lowest GoodRx price for the most common version of generic Sensipar is around $147.07, 82% off the average retail price of $855.11.

What is cinacalcet prescribed for?

Cinacalcet is used to treat hyperparathyroidism in patients with chronic kidney disease who are on dialysis. Hyperparathyroidism is a condition that is caused when the parathyroid glands located in the neck make too much parathyroid hormone ( PTH ).

Is hydrochloride a narcotic?

Naloxone hydrochloride, a narcotic antagonist, is a synthetic congener of oxymorphone . In structure it differs from oxymorphone in that the methyl group on the nitrogen atom is replaced by an allyl group.

What is the formula for hydrochloride?

Hydrochloride. For example, reacting pyridine (C 5 H 5 N) with hydrochloric acid (HCl) yields its hydrochloride salt, pyridinium chloride. The molecular formula is either written as C 5 H 5 N·HCl or as C 5 H 5 NH + Cl − .