What does 8 8 isoprostane mean?
What does 8 8 isoprostane mean?
8 Isoprostane. 8-Isoprostanes are elevated in tissue subjected to increased oxidative stress, and can be extracted and measured quantitatively using several methods including an enzyme-linked immunoassay. From: Heart Failure: A Companion to Braunwald’s Heart Disease (Second Edition), 2011.
Does 8-isoprostane increase oxidative stress in asthma patients?
There was no correlation between 8-isoprostane and lung function tests in any group of patients. Our study shows that oxidative stress is increased in asthmatic subjects as reflected by 8-isoprostane concentrations in breath condensate. Oxidative stress has an important role in the pathophysiology of asthma ( 1 ).
Can isoprostanes be used to quantify oxidative stress in vivo?
There is evidence for an imbalance between oxidants and antioxidants in patients with stable and acute asthma ( 8 ). Recently, isoprostanes have been used to quantify oxidative stress in vivo. Measurements of these compounds in biologic fluid may therefore provide a quantitative index of oxidant stress in vivo ( 9 ).
Is 8-isoprostane elevated in obese mice?
Serum circulating concentrations of 8-isoprostane are increased in congenitally obese ob/ob mice [123], as well as in rats on a high-fat diet [127,130]. Similar elevated levels of 8-isoprostane have been described in the urine of obese subjects [131,132] and obese Zucker rats [133].
