What does Aurora a kinase do?
What does Aurora a kinase do?
Aurora kinases are serine/threonine kinases that are essential for cell proliferation. They are phosphotransferase enzymes that help the dividing cell dispense its genetic materials to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation.
What are Aurora kinase inhibitors?
Aurora kinase inhibitors were initially aimed to target solid tumors including ovarian, breast, lung and colon. Despite the wide use of different chemical classes of Aurora kinase inhibitors in clinical trials, a limited efficacy against solid tumors was observed.
Where can you find Aurora A in mitosis?
centrosomes
Indeed, Aurora A is located to centrosomes in G2 and both to centrosomes and to mitotic spindle poles during mitotic spindle assembly. Interestingly, the kinase is also found associated with the central spindle and later on the midbody during mitotic exit.
What is PLK1 gene?
PLK1 (Polo Like Kinase 1) is a Protein Coding gene. Diseases associated with PLK1 include Gonococcal Keratitis and Cataract 36. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Regulation of PLK1 Activity at G2/M Transition.
Where can you find Aurora A and Aurora B during mitosis?
Despite their high degree of homology, Aurora A and B have very distinctive localisations and functions: Aurora A associates with the spindle poles to regulate entry into mitosis, centrosome maturation and spindle assembly; Aurora B is a member of the Chromosomal Passenger Complex (CPC) that transfers from the inner …
How is Plk1 activated?
Like many kinases, Plk1 is activated by phosphorylation in its T loop, which induces a conformational change to promote catalysis. Phosphorylation at that site is also thought to lock the protein in an open conformation, where the kinase domain and the PBD are dissociated.
What does APC Cdc20 do?
Regulation. The APC/CCdc20 complex regulates itself so that it is present during the appropriate times of the cell cycle. Therefore, when cdk activity is high in mitosis, and the cell must prepare to enter anaphase and exit mitosis, the APC/CCdc20 complex is activated.
How does Aurora B regulate chromosome alignment?
Role in chromosome biorientation Studies in several organisms indicate that Aurora B oversees chromosome biorientation by ensuring that appropriate connections are made between spindle microtubules and kinetochores.
