What does C57BL 6 stand for?
What does C57BL 6 stand for?
C57 black 6
C57BL/6, often referred to as “C57 black 6”, “C57” or “black 6”, is a common inbred strain of laboratory mouse. It is the most widely used “genetic background” for genetically modified mice for use as models of human disease.
What is the Substrain of C57BL 6J?
C57BL/6J is the parental substrain; “J” is the laboratory code for The Jackson Laboratory. Therefore, there is no source of “C57BL/6” mice; there is always a longer designation for each substrain indicating the institute or laboratory that maintains the different colonies.
Why are BALB c mice used?
BALB/c mice are useful for research into both cancer and immunology. Most substrains have a “long reproductive life-span”, are noted for displaying high levels of anxiety and for being relatively resistant to diet-induced atherosclerosis, making them a useful model for cardiovascular research.
Why do we use C57BL 6 mice?
C57BL/6 mice is an inbred mouse strain originally developed for the study of antitumor activity and immunology, and is increasingly being used as an basic background strain. It is known that cell-mediated immunity and NK cell activity are of relatively high importance in determining immunological characteristics.
Why are C57BL 6J mice used?
C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. C57BL/6J mice are also commonly used in the production of transgenic mice.
Are C57 mice aggressive?
Some mouse strains are defined by their aggressive nature. Although some consider C57BL/6 mice to be aggressive, in general they are not when compared to other mouse strains.
What does Substrain mean?
Filters. (biology) A subset of a strain, especially one derived from a single cell. noun.
What does C57BL 6J mean?
C57BL/6 substrains. C57BL/6J is the parental substrain; “J” is the laboratory code for The Jackson Laboratory. Therefore, there is no source of “C57BL/6” mice; there is always a longer designation for each substrain indicating the institute or laboratory that maintains the different colonies.
What is a C57BL 6 mouse?
C57BL/6 Mouse | Charles River Laboratories. C57BL/6 mice are the most used inbred strain in research. Our C57BL/6 mouse colonies are genetically identical within each strain, making them free of genetic differences that could impact research results.
Are all C57BL/6 substrains the same?
C57BL/6 substrains are not the same! Once a new C57BL/6 substrain is established, spontaneous mutations will arise in both the original colony, and the new colony. A subset of those mutations will spread through the colony by genetic drift and become fixed (homozygous in all mice).
What is the history of the C57BL 6 strain?
C57BL/6 substrain history. The original C57BL/6 mouse was created by Clarence Cook Little, founder of The Jackson Laboratory, in 1921. Since that time, the strain has been distributed to hundreds of institutes and thousands of laboratories worldwide.
