What does CD34 stand for?

What does CD34 stand for?

CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species. CD34 derives its name from the cluster of differentiation protocol that identifies cell surface antigens. CD34 was first described on hematopoietic stem cells independently by Civin et al.

What is the meaning of hematopoietic?

formation of blood
: the formation of blood or of blood cells in the living body.

What is LT HSC?

Multipotent long-term HSCs (LT-HSCs) reside in the bone marrow and through a process of asymmetric cell division, can self-renew to sustain the stem cell pool or differentiate into short-term HSCs (ST-HSCs) or lineage-restricted progenitors that undergo extensive proliferation and differentiation to produce terminally …

What is blood writing composition and function?

Blood is a specialized body fluid. It has four main components: plasma, red blood cells, white blood cells, and platelets. forming blood clots to prevent excess blood loss. carrying cells and antibodies that fight infection. bringing waste products to the kidneys and liver, which filter and clean the blood.

What is the role of CD34?

CD34 is a membrane protein that aids cells in cell-cell adhesion. Although little is known about its function, CD34 is an important marker for hematopoietic stem cells (HSCs), muscle satellite cells, and endothelial cells.

What is CD34 positive mean?

In normal conditions, CD34-positive cells account for about 1–2% of the total bone marrow cells. The TdT+ subset of precursor B cells (hematogones) is also positive for CD34. Approximately 40% of AMLs and over 50% of ALLs express CD34. CD34 is also expressed in a garden variety of nonhematopoietic tumors.

What type of tissue is hematopoietic?

Hematopoietic and Lymphoid Tissues The hematopoietic tissues arise from hematopoietic stem cells (HSCs) (Fig. 19.1), and include bone marrow, peripheral blood, and certain lymphoid tissue.

Is erythropoiesis and hematopoiesis the same?

Hematopoiesis and erythropoiesis are two processes involved in the formation of mature blood cells. The main difference between hematopoiesis and erythropoiesis is that hematopoiesis is the formation of mature blood cells whereas erythropoiesis is the formation of mature erythrocytes.

What is LSK cell?

KSL cells in cell biology are an early form of mouse/murine hematopoietic stem cells. Lin is a series of lineage marker antigens that identify mature murine blood cells. Hematopoitic stem cells are of interest because of their ability to self-renew and differentiate into every types of blood cell.

What is MPP cells?

ST-HSCs give rise to multipotent progenitors (MPPs) (13). MPPs can support the generation of all mature blood cells types but maintain no obvious self-renewal capacity, and as a consequence, MPPs can only support hematopoiesis transiently (12, 14).

What are the 7 components of blood?

The main components of blood are: plasma. red blood cells. white blood cells….Plasma

• glucose.
• hormones.
• proteins.
• mineral salts.
• fats.
• vitamins.

What are the 3 types of blood?

Blood is made mostly of plasma, but 3 main types of blood cells circulate with the plasma:

• Platelets help the blood to clot. Clotting stops the blood from flowing out of the body when a vein or artery is broken.
• Red blood cells carry oxygen.
• White blood cells ward off infection.