What does dystroglycan do?

What does dystroglycan do?

Dystroglycan is an extracellular matrix receptor involved in adhesion. This protein plays an important role in wound repair of epithelium, and thus may play a role in the progressive impairment of wound repair capacity that occurs in BPD.

Where is dystroglycan?

α-Dystroglycan is a peripheral membrane component of the dystrophin–glycoprotein complex (DGC) found in muscle, nerve, heart, and brain. This protein binds to merosin in extracellular matrix bridging it to the cytoskeleton molecules that include dystrophin and actin.

What is β dystroglycan?

β-Dystroglycan is a single-pass transmembrane protein with a largely unstructured amino-terminal extracellular domain that binds to the carboxy-terminal globular domain of α-dystroglycan (Di et al., 1999; Boffi et al., 2001) and a 121-residue carboxy-terminal cytoplasmic domain that binds directly to the WW, EF, and ZZ …

What is alpha dystroglycan?

α-dystroglycan (α-DG) is an extracellular membrane-associated protein that binds to a variety of extracellular matrix proteins including laminin-α2 [19], while β-dystroglycan (β-DG) is a transmembrane protein that binds strongly to α-DG via its extracellular domain and to dystrophin (and utrophin) via its intracellular …

What is the dystroglycan complex?

The dystroglycan complex contains the transmembrane protein β-dystroglycan and its interacting extracellular mucin-like protein α-dystroglycan. In skeletal muscle fibers, the dystroglycan complex plays an important structural role by linking the cytoskeletal protein dystrophin to laminin in the extracellular matrix.

Where is Pikachurin found?

Pikachurin is the most recently identified dystroglycan ligand protein and is localized in the synaptic cleft in the photoreceptor ribbon synapse.

Where is utrophin found?

the neuromuscular junction
In normal skeletal muscle, utrophin is found at the neuromuscular junction (NMJ) whereas dystrophin predominates at the sarcolemma. However, during development, and in some myopathies including DMD, utrophin is also found at the sarcolemma.

Where does dystrophin attach?

The carboxy-terminal of dystrophin is attached to the sarcolemma, the surface membrane of striated muscle cells,67–70 binding to β-dystroglycan71 and through this to other dystrophin-associated glycoproteins, and to α-dystroglycan, which links the sarcolemma to the extracellular matrix.

Where is laminin located in the body?

basement membrane
Laminin, a large (400–900 kDa) heterotrimeric extracellular glycoprotein, is a major constituent of the basal lamina together with type IV collagen. Laminin-211 (formerly named merosin) is the most abundant laminin isoform in the basement membrane of adult skeletal muscle.

What holds the human body together?

Laminin is the cell adhesion molecule. It’s what holds our bodies together.

Is Pikachu named after the Pika?

According to Nishida, Pikachu’s name originated from the Japanese words, “pika,” which is onomatopoeia for the sound of an electric spark, and “chu,” the sound that a mouse makes. Meanwhile, the name of the animal came from the Tunguse word “piika.”


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