What does FK506 mean?
What does FK506 mean?
FKBP
| FKBP-type peptidyl-prolyl cis-trans isomerase | |
|---|---|
| The human protein FKBP12 bound to FK506 (tacrolimus). The protein surface is colored by hydrophobicity; the deep cleft in which the ligand is bound is hydrophobic. | |
| Identifiers | |
| Symbol | FKBP_C |
| Pfam | PF00254 |
What does the FKBP5 gene do?
An important modulator of stress responses is the FK506-binding protein 51 (FKBP5/FKBP51). FKBP5 acts as a co-chaperone that modulates not only glucocorticoid receptor activity in response to stressors but also a multitude of other cellular processes in both the brain and periphery.
What is FRB protein?
FRB is a small domain derived from full length mTOR. In brief, rapamycin binds to a protein called FKBP12. Rapamycin bound to FKBP12 inhibits mTOR signaling. For your Materials & Methods section: pEGFP-FRB was a gift from Klaus Hahn (Addgene plasmid # 25919 ; http://n2t.net/addgene:25919 ; RRID:Addgene_25919)
What is FKBP5 methylation?
DNA methylation of the FKBP5 gene is assumed to alter FKBP5 expression and hence the synthesis of the FK506 binding protein 51, a central element of a genomic negative feedback loop for glucocorticoid receptor signaling.
Is sirolimus hard on kidneys?
Sirolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also reduce the body’s ability to fight infections.
