What does gp130 do?
What does gp130 do?
gp130 regulates B cell responses IL-6 was identified initially as a B cell growth factor, and subsequent studies have revealed the ability of multiple gp130 signaling cytokines to induce proliferation of B cells [62,–65].
What is gp130 cytokines?
Gp130 cytokines are involved in the regulation of numerous biological processes, including hematopoiesis, immune response, inflammation, cardiovascular action, and neuronal survival. These cytokines share glycoprotein 130 as a common signal transducer in their receptor complex and typically activate STAT3.
What does IL-6 do?
Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions.
What cells express gp130?
The complex of IL-6 and IL-6R associates with the signal-transducing membrane protein gp130, thereby inducing its dimerization and initiation of signaling (15). gp130 is expressed by all cells in the body, whereas IL-6R is mainly expressed by hepatocytes, monocytes/macrophages, and lymphocytes.
Is gp130 a receptor?
Glycoprotein 130 (also known as gp130, IL6ST, IL6R-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of the type I cytokine receptor within the IL-6 receptor family.
What is il6 Covid?
IL-6 is an important cytokine with pleiotropic functions such as metabolic regulation to inflammation, auto-immunity and acute-phase response. COVID-19 patients had high levels of IL-6 that were associated with pulmonary inflammation and extensive lung damage.
Is IL-6 pro or anti-inflammatory?
► The cytokine interleukin-6 (IL-6) has pro- and anti-inflammatory properties. ► Whereas only few cells express the IL-6 receptor and respond to IL-6 (classic signaling), all cells can be stimulated via a soluble IL-6 receptor (trans-signaling) since gp130 is ubiquitously expressed.
Which is a ligand of GP130?
The IL-6 cytokine family — also known as long type I or gp130 cytokines — consists of ciliary neurotrophic factor (CNTF) as well as IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OsM), cardiotrophin 1 (CT-1), and cardiotrophin-like cytokine (CLC) (43).
