What does MLL2 do?
What does MLL2 do?
The KMT2D gene, also known as MLL2, provides instructions for making an enzyme called lysine-specific methyltransferase 2D that is found in many organs and tissues of the body. Lysine-specific methyltransferase 2D functions as a histone methyltransferase.
What does KMT2D do?
KMT2D regulates the induction of adipogenic and myogenic genes and is required for cell-type specific gene expression during differentiation. KMT2C and KMT2D are essential for adipogenesis and myogenesis. Similar functions are seen in neuronal and osteoblast differentiation.
What does KMT2D stand for?
KMT2D (Lysine Methyltransferase 2D) is a Protein Coding gene. Diseases associated with KMT2D include Kabuki Syndrome 1 and Choanal Atresia-Athelia-Hypothyroidism-Delayed Puberty-Short Stature Syndrome.
What is the CARD11 gene?
The CARD11 gene provides instructions for making a protein involved in the function of immune system cells called lymphocytes, particularly certain types called T cells and B cells. These cells identify foreign substances such as bacteria, viruses, and fungi and defend the body against infection.
How common is CDKN2A mutation?
Somatic mutations of CDKN2A are present in up to 95% of pancreatic tumors.
What does MLL2 stand for?
Erik Thunnissen, Egbert F. Smit, in Encyclopedia of Cancer (Third Edition), 2019 MLL2 is a tumor suppressor gene encoding histone H3 lysine 4 (H3K4) mono-methyltransferase, that colocalizes with lineage determining transcription factors on transcriptional enhancers and is essential for cell differentiation and embryonic development.
What is the role of MLL2 in acute myeloid leukemia?
MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia The MLL1 histone methyltransferase gene undergoes many distinct chromosomal rearrangements to yield poor-prognosis leukemia. The remaining wild-type allele is most commonly, but not always, retained.
Does the MLL1 histone methyltransferase gene contribute to leukemogenesis?
The MLL1 histone methyltransferase gene undergoes many distinct chromosomal rearrangements to yield poor-prognosis leukemia. The remaining wild-type allele is most commonly, but not always, retained. To what extent the wild-type allele contributes to leukemogenesis is unclear. Here we show, using ri …
Is mll1/mll2 collaboration in AML through redundancy or regulation of pathways?
We show that MLL1/MLL2 collaboration is not through redundancy, but regulation of distinct pathways. These findings highlight the relevance of MLL2 as a drug target in MLL-rearranged leukemia and suggest its broader significance in AML.
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