What does monoclonal B-cell lymphocytosis mean?

What does monoclonal B-cell lymphocytosis mean?

Monoclonal B lymphocytosis (MBL) is defined as the presence of a clonal B-cell population in the peripheral blood with fewer than 5 × 109/L B-cells and no other signs of a lymphoproliferative disorder. The majority of cases of MBL have the immunophenotype of chronic lymphocytic leukemia (CLL).

Is monoclonal B-cell lymphocytosis a cancer?

Monoclonal B-cell lymphocytosis (MBL) is a non-cancerous condition. This condition causes an increased number of abnormal B-cells called lymphocytes in the blood.

What is the most common cause of reactive lymphocytosis?

Common causes of reactive lymphocytosis: infections (EBV, CMV, pertussis, cat-scratch disease, HIV, etc.), drug reactions (DRESS), stress, and asplenia. Common causes of lymphocytosis secondary to monoclonal expansion: CLL/SLL, MBL (ALC under 5000 cells/microL), NHL (MZL, FL, MCL), T-LGL, HCL, Scezary syndrome.

What do reactive lymphocytes indicate?

Reactive lymphocytes are immune-stimulated lymphocytes with upregulated synthesis of inflammatory mediators, and/or immunoglobulins (antibodies), or both. Reactive lymphocytes in peripheral blood suggest active, systemic antigenic stimulation secondary to both infectious and noninfectious disorders.

Does B cell lymphoma spread?

When you have B-cell lymphoma, your body makes too many abnormal B cells. These cells can’t fight infections well. They can also spread to other parts of your body.

Can MBL be cured?

MBL is a condition that resembles CLL, but isn’t classed as leukaemia as there aren’t enough abnormal cells present. MBL doesn’t require treatment, but you will need regular blood tests to monitor your lymphocyte count. A small number of people with MBL develop CLL that requires treatment.

Can you have leukemia for years without knowing?

Chronic leukemia involves more-mature blood cells. These blood cells replicate or accumulate more slowly and can function normally for a period of time. Some forms of chronic leukemia initially produce no early symptoms and can go unnoticed or undiagnosed for years.

What conditions cause lymphocytosis?

Specific causes of lymphocytosis include:

• Acute lymphocytic leukemia.
• Chronic lymphocytic leukemia.
• Cytomegalovirus (CMV) infection.
• Hepatitis A.
• Hepatitis B.
• Hepatitis C.
• HIV/AIDS.
• Hypothyroidism (underactive thyroid)

What happens if basophils count is high?

It can be caused by infections, severe allergies, or an overactive thyroid gland. An abnormally high basophil level is called basophilia. It can be a sign of chronic inflammation in your body. Or it can mean that a condition is causing too many white blood cells to be produced in your bone marrow.

What characteristics are associated with reactive lymphocytes?

Reactive lymphocytes are large, immune-stimulated lymphocytes with dark-blue cytoplasm and irregular, scalloped, or cleaved nuclei.

What type of infection does lymphocytosis indicate?

In many cases, lymphocytosis simply means your body has been fighting a viral infection. In some cases, lymphocytosis is one of the first signs of certain blood cancers, including chronic lymphocytic leukemia (CLL), which is the most common type of leukemia seen in adults.