What does NKp46 bind to?
What does NKp46 bind to?
NKp46 has been described to bind the intracellular filamentous cytoskeletal protein vimentin expressed on the surface of Mycobacterium tuberculosis–infected monocytes (25).
Do all NK cells express NKp46?
NKp46 is uniquely expressed on all NK cell subsets and has been suggested as a possible target for NK cell ablation and as a pan NK cell marker (19, 20).
What are Natural Cytotoxicity receptors?
Natural cytotoxicity receptors (NCRs) are expressed almost exclusively by natural killer (NK) cells and play a central role in triggering their activation. In humans, NKp30, NKp46, and NKp80 are constitutively expressed on resting and activated NK cells, while NKp44 expression is induced following activation.
What is CD16 a marker for?
CD16 is often used as an additional marker to reliably identify different subsets of human immune cells. Several other CD molecules, such as CD11b and CD33, are traditionally used as markers for human myeloid-derived suppressor cells (MDSCs).
Do NKT cells express NKp46?
Walzer et al. proposed that the phenotypic identification of NK cells across species is CD3–NKp46+ (24, 25). However, NKp46 is also expressed on a minute fraction of CD3+ cells in mice, while it is not expressed on CD1d-restricted NKT cells (24).
What is CD56 marker?
CD56 is the archetypal phenotypic marker of natural killer cells but can actually be expressed by many more immune cells, including alpha beta T cells, gamma delta T cells, dendritic cells, and monocytes.
What are killer cells and what do they do?
Natural killer cells, also known as NK cells or large granular lymphocytes (LGL), are a type of cytotoxic lymphocyte critical to the innate immune system that belong to the rapidly expanding family of innate lymphoid cells (ILC) and represent 5–20% of all circulating lymphocytes in humans.
Where do natural killer cells come from?
“Natural killer cells burst forth from the the tonsils, lymph nodes and spleen, and destroy infected and cancerous cells while the immune system’s T and B cells are still mobilizing,” says Münz.
Do all NK cells express CD16?
Two NK-cell populations are found in the peripheral blood: the majority (around 90%) express CD56 in intermediate levels and are CD16+, while the remaining NK cells are CD56 bright but do not express CD16 [5].
Where is CD16 expressed?
macrophages
CD16 is expressed on macrophages, natural killer (NK) cells and neutrophils. Their expression is constitutive, although cytokines and lymphokines can modulate their expression levels.
