What does rpS6 do?
What does rpS6 do?
Ribosomal protein S6 (rpS6 or eS6) is a component of the 40S ribosomal subunit and is therefore involved in translation. Mouse model studies have shown that phosphorylation of eS6 is involved in the regulation of cell size, cell proliferation, and glucose homeostasis.
What is p rpS6?
Phosphorylated ribosomal S6 (p-rpS6) as a post-treatment indicator of HER2 signalling targeted drug resistance. Biomarkers.
What type of protein is in ribosomes?
ribosomal proteins
Ribosomes are made up of ribosomal proteins and ribosomal RNA (rRNA). In prokaryotes, ribosomes are roughly 40 percent protein and 60 percent rRNA. In eukaryotes, ribosomes are about half protein and half rRNA.
What is ribosomes and its function?
A ribosome functions as a micro-machine for making proteins. Ribosomes are composed of special proteins and nucleic acids. The TRANSLATION of information and the Linking of AMINO ACIDS are at the heart of the protein production process. Ribosomes can join up amino acids at a rate of 200 per minute.
What does 70S ribosome mean?
Bacteria and archaebacteria have smaller ribosomes, termed 70S ribosomes, which are composed of a small 30S subunit and large 50S subunit. The “S” stands for svedbergs, a unit used to measure how fast molecules move in a centrifuge.
What are the two main functions of ribosomes?
Ribosomes have two main functions — decoding the message and the formation of peptide bonds. These two activities reside in two large ribonucle- oprotein particles (RNPs) of unequal size, the ribosomal subunits. Each subunit is made of one or more ribosomal RNAs (rRNAs) and many ribosomal proteins (r-pro- teins).
What does mTOR do in autophagy?
As outlined above, mTOR promotes anabolic cellular processes leading to growth. This is further facilitated by the suppression of protein catabolism, most notably autophagy. Autophagy is a basic catabolic process in the cell that degrades damaged organelles or dysfunctional proteins to gain energy or free amino acids.
What is the function of rpS6?
Ribosomal protein S6 ( rpS6 or eS6) is a component of the 40S ribosomal subunit and is therefore involved in translation. Mouse model studies have shown that phosphorylation of eS6 is involved in the regulation of cell size, cell proliferation, and glucose homeostasis.
What is the mediator of rpS6 in tuberous sclerosis?
Rheb is a mediator of RPS6. Cortical tuber giant cells in a case of epileptogenic tuberous sclerosis showed predominantly nuclear hamartin, cytosolic tuberin, and hyperphosphorylation of S6. IFNgamma-activated p70 S6 kinase phosphorylates the 40S S6 ribosomal protein on serines 235/236, to regulate IFNgamma-dependent mRNA translation.
Is ribosomal protein S6 (rpS6) a tumor marker for renal cell carcinoma?
Data suggest ribosomal protein S6 (rpS6) as tumor marker for renal cell carcinoma. Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation. Tanshinone IIA inhibits HIF-1alpha and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway.
What is the function of ribosomal protein S6?
Ribosomal protein s6. Ribosomal protein S6 ( rpS6) is a component of the 40S ribosomal subunit and is therefore thought to be involved in regulating translation. While the true function of rpS6 is currently under investigation, mouse model studies have shown that it is involved in the regulation of cell size, cell proliferation,…
