What does the L stand for in L-asparaginase?

What does the L stand for in L-asparaginase?

Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the G1 phase, and apoptosis in susceptible leukemic cell populations.

What type of drug is L-asparaginase?

Enzyme
Asparaginase/Classification

How is L-asparaginase given?

Aspariginase is given as an injection into a large muscle (intramuscular or IM). Depending on your dose, the medication may need to be divided into two injections. Also may be given into the vein as an infusion (intravenous or IV). This method has higher risk of allergic reaction so often a test dose is given first.

What is asparaginase used for?

Asparaginase erwinia chrysanthemi is used with other chemotherapy medications to treat acute lymphocytic leukemia (ALL; a type of cancer of the white blood cells).

What is Laspar?

Laspar 5000IU Injection is used in the treatment of some kinds of cancer of white blood cells (leukemia). It may also be used to treat other types of cancer as determined by your doctor. It may be used on its own, or sometimes given together with certain other medicines as part of combination chemotherapy.

How do you reconstitute asparaginase?

When ELSPAR is administered intramuscularly according to the schedule cited in the induction regimen, reconstitution is carried out by adding 2 mL Sodium Chloride Injection to the 10,000 unit vial. The resulting solution should be used within eight hours and only if clear.

Is asparaginase in asparagus?

Asparagine is an amino acid – the building blocks that cells use to make proteins. While the body can make asparagine, it’s also found in our diet, with higher concentrations in some foods including, asparagus.

What is spar?

Basic Information. L-Asparaginase is a chemotherapy drug that is used in veterinary medicine to treat cats and dogs that are suffering from certain types of cancers known to affect the immune system, but predominantly to treat lymphoma. All cells need asparaginase to produce protein.

What is asparaginase and how does it work?

Asparaginase works by breaking down the amino acid known as asparagine without which the cancer cells cannot make protein.

What is the fundamental structure of asparagine?

This revealed the molecule’s fundamental structure: a chain of four carbon atoms. Piria thought that asparagine was a diamide of malic acid; however, in 1862 the German chemist Hermann Kolbe showed that this surmise was wrong; instead, Kolbe concluded that asparagine was an amide of an amine of succinic acid.

Is asparaginase safe to use during pregnancy?

Use in pregnancy may harm the baby. As a food it is generally recognized as safe. Asparaginase works by breaking down the amino acid known as asparagine without which the cancer cells cannot make protein.

Is asparagine an essential amino acid?

Asparagine (Asn) is one of the 20 most common natural amino acids on Earth. It has carboxamide as the side chain’s functional group. Asparagine is not an essential amino acid, which means that it can be synthesized from central metabolic pathway intermediates in humans and is not required in the diet.