What drug is ERK?
What drug is ERK?
ERK 1/2 inhibitor ASTX029
| Synonym: | ERK inhibitor ASTX029 extracellular signal-regulated kinase 1/2 inhibitor ASTX029 extracellular signal-regulated kinase inhibitor ASTX029 |
|---|---|
| Code name: | ASTX 029 ASTX-029 ASTX029 |
What does ERK stand for kinase?
extracellular-signal-regulated kinase
The extracellular-signal-regulated kinase (ERK) pathway is one of the major signaling cassettes of the mitogen activated protein kinase (MAPK) signaling pathway.
What type of regulatory enzyme is ERK?
ERK is a promiscuous kinase and can phosphorylate more than 100 different substrates. Therefore activation of ERK can affect a broad array of cellular functions including proliferation, survival, apoptosis, motility, transcription, metabolism and differentiation.
What does MAPK pathway do?
MAPK pathways relay, amplify and integrate signals from a diverse range of stimuli and elicit an appropriate physiological response including cellular proliferation, differentiation, development, inflammatory responses and apoptosis in mammalian cells.
How does the ERK/MAPK pathway work?
The ERK/MAPK pathway delivers signals from cellular surface receptors via ERK pathway. Briefly, different cellular surface receptors such as EGFR, GPCR, and RKT are activated by the corresponding extracellular factors (e.g., growth factors, hormones, and stresses) to activate Ras and small GTPase.
What does MAPK stand for?
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions Conserved signaling pathways that activate the mitogen-activated protein kinases (MAPKs) are involved in relaying extracellular stimulations to intracellular responses.
What are mitogen-activated protein kinases?
Mitogen-activated protein kinases (MAPKs) include ERK, p38, and JNK MAPK subfamilies, which are crucial regulators of cellular physiology, cell pathology, and many diseases including cancers.
What is the function of the MAPKs?
The MAPKs coordinately regulate cell proliferation, differentiation, motility, and survival, which are functions also known to be mediated by members of a growing family of MAPK-activated protein kinases (MKs; formerly known as MAPKAP kinases).
