What enzyme does the Cdc25 gene encode?
What enzyme does the Cdc25 gene encode?
Chr. Chr. M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene. This gene is highly conserved during evolution and it plays a key role in the regulation of cell division.
What happens when Cdc25 is overexpressed?
Overexpression of CDC25 leads to over-activation of several CDKs resulting in cell cycle progression in an untimely manner by disregarding the checkpoint barrier. This contributes to cancer development and genomic instability.
Does phosphorylation activate Cdc25?
The M-phase inducer, Cdc25C, is a dual-specificity phosphatase that directly phosphorylates and activates the cyclin B/Cdc2 kinase complex, leading to initiation of mitosis. Cdc25 itself is activated at the G2/M transition by phosphorylation on serine and threonine residues.
What is WEE1 inhibitor?
It has been proposed that WEE1 inhibitor promotes cancer cells to prematurely enter mitosis as a result of bypassing the G2 cell-cycle checkpoint [6] as well as delays mitotic exit, resulting in mitotic arrest [7].
What happens if CDC25 is overexpressed?
Since overexpression of Cdc25A is involved in tumor initiation and progression, and correlated with poor prognosis, Cdc25A has been considered as a potential target for cancer therapy [123-125].
How does CDC25 regulate CDK activity?
The activity of CDK is regulated by a series of phosphorylation and dephosphorylation of different residues. Cell Division Cycle-25 (CDC25) plays an important role in transitions between cell cycle phases by dephosphorylating these residues to activate CDKs [3, 4].
What are CDC25 phosphatases and why are they important?
Cell division cycle 25 (CDC25) phosphatases regulate key transitions between cell cycle phases during normal cell division, and in the event of DNA damage they are key targets of the checkpoint machinery that ensures genetic stability.
What is the role of Cdc25 in the cell cycle?
Cell division cycle 25 (CDC25) phosphatases are key regulators of the eukaryotic cell cycle. They are required to control cyclin-dependent kinase (CDK) dephosphorylation and activation in a strict spatio-temporal manner.
What is the molecular weight of CDC25A?
CDC25A, CDC25B, and CDC25C are three subtypes of the CDC25 phosphatase family, the molecular weight between 53 and 65 kDa, and with chain lengths of 524, 580, and 473 amino acids, respectively. The human CDC25 protein family structure has a conserved catalytic domain and a regulatory domain.
What does Cdc25C stand for?
As an important cell cycle regulatory protein, Cell Division Cycle 25C (CDC25C) participates in regulating G2/M progression and in mediating DNA damage repair.
