What is a Beckman PSA?
What is a Beckman PSA?
phi is a proprietary calculation developed by Beckman Coulter Inc. that uses a combination of three blood tests to produce a “phi score.” This phi score provides more information about what elevated PSA levels might mean and the probability of finding prostate cancer on biopsy.*
What is a normal prostate health index score?
The prostate health index (phi) is a formula that combines all 3 PSA forms (total PSA, free PSA, and p2PSA) into a single score. phi is calculated using the following formula: (p2PSA/free PSA) x square root of PSA….
| Age | Reference range |
|---|---|
| 60-69 years | < or =4.5 ng/mL |
| 70-79 years | < or =6.5 ng/mL |
| > or =80 years | < or =7.2 ng/mL |
What is a normal p2PSA?
Age-based reference intervals of p2PSA, %p2PSA and phi in healthy males. RIs (2.5th to 97.5th percentiles) for p2PSA, %p2PSA and phi in the overall population were 1.88–17.40 pg/mL and 1.26–4.54, 9.48–45.50, respectively.
What is Hybritech methodology?
The Access® Hybritech® PSA assay is a paramagnetic particle, chemiluminescent immunoassay for the quantitative determination of total prostate specific antigen (PSA) levels in human serum, using the Access® Immunoassay System.
Is Phi better than PSA?
Overall, phi provides superior diagnostic accuracy and better risk stratification than total PSA or %-free PSA as shown by ROC above the curve analysis. At a 95% sensitivity, using phi for risk stratification will result in an improvement in the number of men with benign disease who would be spared from a biopsy.
How much does PSA fluctuate?
PSA fluctuation ranged from 0.12%/month to 122.6%/month, PSAD from 0.01 ng/mL/g to 0.58 ng/mL/g, and prostate volume from 8.9 g to 160 g.
How is p2PSA calculated?
The isoform p2PSA is a promising marker for PCa detection and compared to other isoforms, measurement of the p2PSA to free PSA (%p2PSA) and Prostate Health Index (Phi), which is calculated using the formula (p2PSA/fPSA × √tPSA) can better distinguish between PCa and non-PCa than tPSA and fPSA/tPSA (%fPSA)5,6,7.
What is the difference between PSA and free PSA?
PSA, a protein produced by prostate gland cells, circulates through the body in two ways: either bound to other proteins or on its own. PSA traveling alone is called free PSA. The free-PSA test measures the percentage of unbound PSA; the PSA test measures the total of both free and bound PSA.
Is walking good for your prostate?
The brisk pace is important: One study found that men who walked three or more hours a week at a brisk pace after diagnosis had a 57 percent lower risk of having prostate cancer recur than men who walked at a slower pace, for less than three hours a week. “Just walking, not running! Walking is so common.
What is the probability of prostate cancer based on Beckman Coulter Phi?
Table 1 represents clinical study data analyzed to estimate an individual patient’s probability of having detectable prostate cancer based on Beckman Coulter phi results when that patient has a PSA in the diagnostic gray zone between 4 and 10 ng/mL. 3 At phi cutoffs between 27 to 55, the probability of cancer ranged from 16.8 to 50.1%.‡
What is the Prostate Health Index (Phi)?
Prostate Health Index (phi) An FDA-approved blood test to be used as an aid in distinguishing prostate cancer from benign prostatic conditions 1. The Prostate Health Index (phi) is a calculation that uses a combination of three blood tests to produce a “phi score.”.
Where can I find CPT codes for the Beckman Coulter recommendations?
All three CPT codes within the recommendations are listed on the Medicare Clinical Lab Fee Schedule. For additional information or a copy of the recommendations, please contact the Beckman Coulter Reimbursement Hotline at 800.396.2159.
When to use Beckman Coulter access Hybritech p2psa?
3 Beckman Coulter Access Hybritech p2PSA Instructions for Use. * phi results are intended to be used as an aid in distinguishing prostate cancer from benign prostatic conditions in men 50 years of age and older with total PSA results in the 2 – 10 ng/mL range and negative digital rectal examination DRE findings.
